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Almost 400 publications on HepaRG!

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  • Evaluation of HepaRG cells for the assessment of indirect drug-induced hepatotoxicity using INH as a model substanceMann A, Pelz T, Rennert K, Mosig A, Decker M, Lupp A.
    Hum Cell, May 2017
  • The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cellsGrünig D, Felser A, Bouitbir J, Krähenbühl S.
    Toxicol In Vitro, May 2017
  • N-acetylcysteine potentiates diclofenac toxicity in Saccharomyces cerevisiae: stronger potentiation in ABC transporter mutant strainsAl-Attrache H, Chamieh H, Hamzé M, Morel I, Taha S, Abdel-Razzak Z.
    Drug Chem Toxicol, May 2017
  • Polo-like-kinase 1 is a proviral host-factor for hepatitis B virus replicationDiab AM, Foca A, Fusil F, Lahlali T, Jalaguier P, Amirache F, N'Guyen L, Isorce N1, Cosset FL, Zoulim F, Andrisani OM, Durantel D1.
    Hepatology, Apr 2017
  • Molecular basis of metabolism-mediated conversion of PK11195 from an antagonist to an agonist of the constitutive androstane receptorMackowiak B, Li L, Welch MA, Li D, Jones JW, Heyward S, Kane MA, Swaan PW, Wang H.
    Mol Pharmacol, Apr 2017
  • A Systematic Evaluation of microRNAs in Regulating Human Hepatic CYP2E1.Wang Y, Yu D, Tolleson WH, Yu LR, Green B, Zeng L, Chen Y, Chen S, Ren Z, Guo L, Tong W, Guan H, Ning B.
    Biochem Pharmacol, Apr 2017
  • Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinomaChauhan R, Churchill ND, Mulrooney-Cousins PM, Michalak TI.
    Oncogenesis, Apr 2017
  • Impact of higher-order heme degradation products on hepatic function and hemodynamics.Seidel RA, Claudel T, Schleser FA, Ojha NK, Westerhausen M, Nietzsche S, Sponholz C, Cuperus F, Coldewey SM, Heinemann SH, Pohnert G, Trauner M, Bauer M.
    J Hepatol, Apr 2017
  • Protective effects of an ethanol extract of Angelica keiskei against acetaminophen-induced hepatotoxicity in HepG2 and HepaRG cells.Choi YH, Lee HS, Chung CK, Kim EJ, Kang IJ
    Nutr Res Pract., Apr 2017
  • Poly(malic acid) bearing Doxorubicin and N-Acetyl Galactosamine as a site-specific prodrug for targeting hepatocellular carcinoma.Venkatraj N, Nanjan MJ, Loyer P, Chandrasekar MJ, Cammas Marion S
    J Biomater Sci Polym Ed., Apr 2017
  • Down-regulation of cytochrome P450 2C8 by 3-methylcholanthrene in human hepatocellular carcinoma cell lines.Utgikar R, Riddick DS
    Can J Physiol Pharmacol, Apr 2017
  • Two-color fluorescent cytosine extension assay for the determination of global DNA methylationZhou G, Parfett C, Cummings-Lorbetskie C, Xiao GH, Desaulniers D.
    Biotechniques, Apr 2017
  • Efficient Transfection of Xenobiotic Responsive Element-biosensor plasmid using diether lipid and phosphatidylcholine liposomes in differentiated HepaRG cellsDemazeau M, Quesnot N, Ripoche N, Rauch C, Jefti? J, Morel F, Gauffre F, Benvegnu T, Loyer P
    Int J Pharm, Mar 2017
  • Mechanistic insights in cytotoxic and cholestatic potential of the endothelial receptor antagonists using HepaRG cells.Burbank MG, Sharanek A, Burban A, Mialanne H, Aerts H, Guguen-Guillouzo C, Weaver RJ, Guillouzo A
    Toxicol Sci., Mar 2017
  • An Automated Multiplexed Hepatotoxicity and CYP Induction Assay Using HepaRG Cells in 2D and 3DOtt LM, Ramachandran K, Stehno-Bittel L
    SLAS Discov., Mar 2017
  • Longitudinal in vivo bioimaging of hepatocyte transcription factor activity following cholestatic liver injury in miceDelhove JM, Buckley SM, Perocheau DP, Karda R, Arbuthnot P, Henderson NC, Waddington SN, McKay T.
    Sci Rep, Feb 2017
  • A transcriptomic study suggesting human iPSC-derived hepatocytes potentially offer a better in vitro model of hepatotoxicity than most hepatoma cell lines.Gao X, Liu Y
    Cell Biol Toxicol, Jan 2017
  • Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver.Gamal W, Treskes P, Samuel K, Sullivan GJ, Siller R, Srsen V, Morgan K, Bryans A, Kozlowska A, Koulovasilopoulos A, Underwood I, Smith S, Del-Pozo J, Moss S, Thompson AI, Henderson NC, Hayes PC, Plevris JN, Bagnaninchi PO, Nelson LJ.
    Sci Rep, Jan 2017
  • Transcriptional, functional and mechanistic comparisons of stem cell-derived hepatocytes, HepaRG cells and 3D human hepatocyte spheroids as predictive in vitro systems for drug-induced liver injury.Bell CC, Lauschke VM, Vorrink SU, Palmgren H, Duffin R, Andersson TB, Ingelman-Sundberg M.
    Drug Metab Dispos, Jan 2017
  • Hepatocellular Toxicity of Imidazole and Triazole Antimycotic Agents.Haegler P, Joerin L, Krähenbühl S, Bouitbir J
    Toxicol Sci., Jan 2017
  • Tailored LC-MS analysis improves the coverage of the intracellular metabolome of HepaRG cells.Cuykx M et al. Tailored LC-MS analysis improves the coverage of the intracellular metabolome of HepaRG cells.. AK390J Chromatogr A January-23;
    J Chromatogr A, Jan 2017
  • Impact of IL-27 on hepatocyte antiviral gene expression and function.Ramamurthy N, Boninsegna S, Adams R, Sahgal N, Lockstone H, Baban D, Marchi E, Klenerman P
    Wellcome Open Res., Jan 2017
  • The virtual cell based assay: Current status and future perspectivesGraepel R, Lamon L, Asturiol D, Berggren E, Joossens E, Paini A, Prieto P, Whelan M, Worth A
    Toxicol In Vitro, Jan 2017
  • A novel toolbox for the in vitro assay of hepatitis D virus infectionZhao JH, Zhang YL, Zhang TY, Yuan LZ, Cheng T, Chen PJ, Yuan Q, Xia NS
    Sci Rep., Jan 2017
  • Netrin-1 Protects Hepatocytes Against Cell Death Through Sustained Translation During the Unfolded Protein ResponseLahlali T, Plissonnier ML, Romero-López C, Michelet M, Ducarouge B, Berzal-Herranz A, Zoulim F, Mehlen P, Parent R.
    Cell Mol Gastroenterol Hepatol, Jan 2017
  • CYP4F2 repression and a modified alpha-tocopherol (vitamin E) metabolism are two independent consequences of ethanol toxicity in human hepatocytes.Russo A, Bartolini D, Torquato P, Giusepponi D, Barola C, Galarini R, Birringer M, Lorkowski S, Galli F
    Toxicol In Vitro, Jan 2017


  • Structure-activity relationship for branched oxyquinoline HIF activators: Effect of modifications to phenylacetamide "tailPoloznikov AA, Zakhariants AA, Nikulin SV, Smirnova NA, Hushpulian DM, Gaisina IN, Tonevitsky AG, Tishkov VI, Gazaryan IG.
    Biochimie, Dec 2016
  • Hepatitis B Virus Infection of HepaRG Cells, HepaRG-hNTCP Cells, and Primary Human Hepatocytes.Ni Y, Urban S
    Methods Mol Biol, Dec 2016
  • Suppression of miR-628-3p and miR-641 is involved in rifampin-mediated CYP3A4 induction in HepaRG cells.Yan L, Liu J, Zhao Y, Nie Y, Ma X, Kan Q, Zhang L
    Pharmacogenomics, Dec 2016
  • Development of a Specific Substrate-Inhibitor Panel (Liver-on-a-Chip) for Evaluation of Cytochrome P450 Activity.Zakhariants AA, Burmistrova OA, Shkurnikov MY, Poloznikov AA, Sakharov DA
    Bull Exp Biol Med, Nov 2016
  • Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail.Berger B, Donzelli M, Maseneni S, Boess F, Roth A, Krähenbühl S, Haschke M
    Front Pharmacol, Nov 2016
  • Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor.Carazo A, Hyrsova L, Dusek J, Chodounska H, Horvatova A, Berka K, Bazgier V, Gan-Schreier H, Chamulitrat W, Kudova E, Pavek P.
    Toxicol Lett, Nov 2016
  • Impact of IL-27 on hepatocyte antiviral gene expression and function.Ramamurthy N, Boninsegna S, Adams R, Sahgal N, Lockstone H, Baban D, Marchi E, Klenerman P.
    Wellcome Open Res, Nov 2016
  • Increase of Intracellular Cyclic Amp by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and SurvivalMassimi M, Cardarelli S, Galli F, Giardi MF, Ragusa F, Panera N, Cinque B, Cifone MG, Biagioni S, Giorgi M.
    J Cell Biochem, Nov 2016
  • Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acidAbe T, Takahashi M, Kano M, Amaike Y, Ishii C, Maeda K, Kudoh Y, Morishita T, Hosaka T, Sasaki T, Kodama S, Matsuzawa A, Kojima H, Yoshinari K
    Arch Toxicol, Nov 2016
  • Induction of expression of aryl hydrocarbon receptor-dependent genes in human HepaRG cell line modified by shRNA and treated with ?-naphthoflavoneBrauze D, Zawierucha P, Kiwerska K, Bednarek K, Oleszak M, Rydzanicz M, Jarmuz-Szymczak M
    Mol Cell Biochem, Oct 2016
  • iTRAQ-based Membrane Proteomics Reveals Plasma Membrane Proteins Change During HepaRG Cell DifferentiationZhao M, Xu F,  Wu F, Yu D, Su N, Zhang Y, Cheng L, Xu P
    J Proteome Res, Oct 2016
  • Stable overexpression of the constitutive androstane receptor reduces the requirement for culture with dimethyl sulfoxide for high drug metabolism in HepaRG cells.Van der Mark VA,  de Waart DR,  Shevchenko V,  Oude Elferink RP
    Drug Metab Dispos, Oct 2016
  • HDV RNA replication is associated with HBV repression and interferon-stimulated genes induction in super-infected hepatocytes.Alfaiate, Lucifora, Abeywickrama-Samarakoon, Michelet, Testoni, Cortay, Sureau, Zoulim, Dény, Durantel, , ,
    Antiviral research, Oct 2016
  • Practical use of the Virtual Cell Based Assay: Simulation of repeat exposure experiments in liver cell linesPaini A, Mennecozzi M, Horvat T, Gerloff K, Palosaari T, Benito JV, Worth A
    Toxicol In Vitro, Oct 2016
  • Design, Synthesis, and Cytotoxicity of 5-Fluoro-2-methyl-6-(4-aryl-piperazin-1-yl) Benzoxazoles.Al-Harth,  Zoghaib WM, Pflüger M, T Schöpel M, Önder K, Reitsammer M, Hundsberger H,  Stoll R, Abdel-Jalil R
    Molecules, Sep 2016
  • Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug CandidatesLauschke VM,  Hendriks DF1,  Bell CC,  Andersson TB,  Ingelman-Sundberg M
    Chem Res Toxicol, Sep 2016
  • Evaluation of a novel PXR-knockout in HepaRG cellsWilliamson B, Lorbeer M, Mitchell MD, Brayman TG, Riley RJ
    Pharmacol Res Perspect, Sep 2016
  • Opsonisation of nanoparticles prepared from poly(?-hydroxybutyrate) and poly(trimethylene carbonate)-b-poly(malic acid) amphiphilic diblock copolymers: Impact on the in vitro cell uptake by primary human macrophages and HepaRG hepatoma cells.Vene E,  Barouti G,  Jarnouen K,  Gicquel T,  Rauch C,  Ribault C,  Guillaume SM,  Cammas-Marion S,  Loyer P
    Int J Pharma, Sep 2016
  • Early alterations of bile canaliculi dynamics and the ROCK/MLCK pathway are characteristics of drug-induced intrahepatic cholestasis.Burbank MG,  Burban A,  Sharanek A,  Weaver RJ,  Guguen-Guillouzo C,  Guillouzo A,
    Drug Metab Dispos, Aug 2016
  • A modified multiparametric assay using HepaRG cells for predicting the degree of drug-induced liver injury risk.Tomida T,  Okamura H,  Yokoi T,  Konno Y,
    J Appl Toxicol., Aug 2016
  • New screening criteria setting on evaluation of cytochrome P450 induction using HepaRG cells with multiplex branched DNA technologies in early drug discovery.Ogasawara A,  Yamada Y,  Torimoto N,  Tsuda N,  Aohara F,  Ohashi R,  Taniguchi H., , , , , ,
    Drug Metab Lett., Aug 2016
  • Metformin Protects against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.Du K,  Ramachandran A,  Weemhoff JL,  Chavan H,  Xie Y,  Krishnamurthy P,  Jaeschke H, , , , , ,
    Toxicol Sci., Aug 2016
  • Accessing 3D microtissue metabolism : Lactate and oxygen monitoring in hepatocyte spheroids.Weltin A, Hammer S, Noor F, Kaminski Y, Kieninger J, Urban GA
    Biosens Bioelectron, Jul 2016
  • Optimization, formulation, and characterization of multiflavonoids-loaded flavanosome by bulk or sequential technique.Karthivashan G,  Masarudin MJ,  Kura AU,  Abas F,  Fakurazi S, , , , , , , ,
    Int J Nanomedicine, Jul 2016
  • Effect of Circulation Parameters on Functional Status of HepaRG Spheroids Cultured in Microbioreactor.Semenova OV,  Petrov VA,  Gerasimenko TN,  Aleksandrova AV,  Burmistrova OA,  Khutornenko AA,  Osipyants AI,  Poloznikov AA,  Sakharov DA, , , ,
    Bull Exp Biol Med, Jul 2016
  • Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity.Fukami T,  Iida A,  Konishi K,  Nakajima M, , , , , , , , ,
    Biochem Pharmacol, Jul 2016
  • Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate.Sayyed K,  Vee ML,  Abdel-Razzak Z,  Jouan E,  Stieger B,  Denizot C,  Parmentier Y,  Fardel O, , , , ,
    Toxicology, Jul 2016
    J Virol, Jul 2016
  • Metabolic fate of desomorphine elucidated using rat urine, pooled human liver preparations, and human hepatocyte cultures as well as its detectability using standard urine screening approaches.Richter LH,  Kaminski YR,  Noor F,  Meyer MR,  Maurer HH
    Anal Biocanal Chem, Jul 2016
  • In vitro hepatotoxicity of 'Legal X': the combination of 1-benzylpiperazine (BZP) and 1-(m-trifluoromethylphenyl)piperazine (TFMPP) triggers oxidative stress, mitochondrial impairment and apoptosis.Dias da Silva D,  Silva MJ,  Moreira P,  Martins MJ,  Valente MJ,  Carvalho F,  Bastos ML,  Carmo H, , , , ,
    Archives of toxicology, Jun 2016
  • A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.Sison-Young RL , Lauschke VM, Johann E, Alexandre E, Antherieu S, Aerts H, Gerets HH, Labbe G, Hoet D, Dorau M, Schofield CA, Lovatt CA, Holder JC
    Archives of toxicology, Jun 2016
  • Contextualizing Hepatocyte Functionality of Cryopreserved HepaRG® Cell CulturesBucher S, Jalili P, Le Guillou D, Begriche K, Rondel K, Martinais S, Zalko D, Corlu A, Robin A, Fromenty B, , , Jackson JP, Li L, Chamberlain ED, Wang H, Ferguson SS
    Drug metabolism and disposition, Jun 2016
  • Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure.Bucher S, Jalili P, Le Guillou D, Begriche K, Rondel K, Martinais S, Zalko D, Corlu A, Robin A, Fromenty B
    Environmental toxicology, Jun 2016
  • The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cellsNunn AD, Scopigno T, Pediconi N, Levrero M, Hagman H, Kiskis J, Enejder A, , , , , ,
    Scientific Reports, Jun 2016
  • Selecting Cells for Bioartificial Liver Devices and the Importance of a 3D Culture Environment: A Functional Comparison between the HepaRG and C3A Cell Lines.van Wenum M,  Adam AA,  Hakvoort T, Hendriks EJ,  Shevchenko V,  van Gulik TM,  Chamuleau RA,  Hoekstra R., , , , ,
    Int J Biol Sci., Jun 2016
  • MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes.Jin Y, Yu D, Tolleson WH, Knox B, Wang Y, Chen S, Ren Z, Deng H, Guo Y, Ning B
    Biochemical pharmacology, Jun 2016
  • Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-?.Al-Attrache H, Sharanek A, Burban A, Burbank M, Gicquel T, Abdel-Razzak Z, Guguen-Guillouzo C, Morel I, Guillouzo A
    toxicology letters, Jun 2016
  • Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications.Nelson LJ, Morgan K, Treskes P, Samuel K, Henderson CJ, LeBled C, Homer N, Helen Grant M, Hayes PC, Plevris JN
    Basic & Clinical Pharmacology & Toxicology, Jun 2016
  • Complex Approach to Xenobiotics Hepatotoxicity Testing using a Microfluidic System.Aleksandrova AV, Pul'kova NV, Sakharov DA
    Bulletin of experimental biology and medecine, Jun 2016
  • Maintenance of High Cytochrome P450 Expression in HepaRG Cell Spheroids in DMSO-Free Medium.Aleksandrova AV, Burmistrova OA, Fomicheva KA, Sakharov DA
    Bulletin of experimental biology and medecine, Jun 2016
  • Characterization of hepatotoxicity mechanisms triggered by designer cathinone drugs (?-keto amphetamines).Valente MJ, Araujo AM, Bastos ML, Fernandes E, Carvahlo F, Guedes de Pinho P, Carvalho M
    Toxicological Sciences, Jun 2016
  • Reciprocal regulation of farnesoid X receptor ? activity and hepatitis B virus replication in differentiatedHepaRG cells and primary human hepatocytes.Radreau P, Porcherot M, Ramière C, Mouzannar K , Lotteau V, André P
    FASEB journal, Jun 2016
  • A Rapid and Sensitive HPLC-DAD Assay to Quantify Lamotrigine, Phenytoin and Its Main Metabolite in Samples of Cultured HepaRG Cells.Ferreira A, Rodrigues M, Falcao A, Alves G
    Journal of chromatographic science, May 2016
  • De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas.Mebarki S, Désert R, Sulpice L, Sicard M, Desille M, Canal F, Schneider HD, Bergeat D, Turlin B, Bellaud P, Lavergne E, Le Guevel R, Corlu A
    Oncotarget, May 2016
  • Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs.Sharanek A, Burban A, Burbank M, Le Guevel R, Li R, Guillouzo A, Guguen-Guillouzo C
    Scientific Reports, May 2016
  • Mathematical and Experimental Model of Oxygen Diffusion for HepaRG Cell Spheroids.Aleksandrova AV, Pulkova NV, Gerasimenko TN, Anisimov NY, Tonevitskaya SA, Sakharov DA
    Bulletin of experimental biology and medecine, May 2016
  • Transport and Toxicity of Silver Nanoparticles in HepaRG Cell Spheroids.Senyavina NV, Gerasimenko TN, Pulkova NV, Maltseva DV, , , , , , , , ,
    Bulletin of experimental biology and medecine, May 2016
  • Maintenance of Hepatic Progenitor-like Characteristics of HepaRG Cells by Cultivation on VECELL Inserts"Takashi Kubo, Yukie Kuroda, Maki Hojyo, Su-Ryang Kim, Shinichiro Horiuchi, Yuko Sekino, Fabrice Morel, Anne Corlu, and Seiichi Ishida"
    AATEX, May 2016
  • NOD1 participates in the innate immune response triggered by the hepatitis C viral polymerase.Vegna S, Gregoire D, Moreau M, Lassus P, Durantel D, Assenat E, Hibner U, Simonin Y
    journal of virology, Apr 2016
  • Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis.Tolosa L, Gomez-Lechon MJ, Jimenez N, Hervas D, Jover R, Donato MT
    toxicology and applied pharmacology, Apr 2016
  • Novel roles for AhR and ARNT in the regulation of alcohol dehydrogenases in human hepatic cells.Attignon EA, Leblanc AF, Le Grand B, Duval C, Aggerbeck M, Rouach H, Blanc EB, , , , , ,
    Archives of toxicology, Apr 2016
  • The HepaRG cell line, a superior in vitro model to L-02, HepG2 and hiHeps cell lines for assessing drug-induced liver injury.Wu Y, Geng XC, Wang JF, Miao YF,  Lu YL,  Li B
    Cell Biol Toxicol., Mar 2016
  • Grouping Thirty Four Chemicals Based on Mode of Action Using Connectivity Mapping.De Abrew KN,  Kainkaryam RM, Shan YK, Overmann GJ,  Settivari RS, Wang X, Xu j, Adams RL, Tiesman JP,  Carney EW, Naciff JM, Daston GP
    Toxicol Science, Mar 2016
  • Antiviral activity of various interferons and pro-inflammatory cytokines in non-transformed cultured hepatocytes infected with hepatitis B virus.Isorce N, Testoni B, Locatelli M, Fresquet J, Rivoire M, Luangsay S, Zoulim F, Durantel D
    Antiviral research, Mar 2016
  • Engineering EMT using 3D micro-scaffold to promote hepatic functions for drug hepatotoxicity evaluation.Wang J, Chen F, Liu L, Qi C, Wang B, Yan X, Huang C, Hou W, Zhang MQ, Chen Y, Du Y
    Biomaterials, Mar 2016
  • Modulation of CYP3A4 activity alters the cytotoxicity of lipophilic phycotoxins in human hepatic HepaRG cells.Ferron PJ , Hogeveen K, De Sousa G, Rahmani R, Dubreil E, Fessard V, Le Hegarat L
    Toxicology in vitro, Mar 2016
  • Establishment of a Drug-Induced, Bile Acid-Dependent Hepatotoxicity Model Using HepaRG Cells.Susukida T, Sekine S, Nozaki M, Tokizono M, Oizumi K, Horie T, Ito K
    Journal of pharmaceutical sciences, Mar 2016
  • HBV culture and infectious systems.Hayes CN Chayama K
    Hepatology international, Mar 2016
  • The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by squelching SRC-1 coactivator.Hyrsova L, Smutny T, Carazo A, Moravcik S, Mandikova J, Trejtnar F, Gerbal-Chaloin S, Pavek P
    British journal of pharmacology, Feb 2016
  • Disruption of BSEP Function in HepaRG cells Alters Bile Acid Disposition and is a susceptive factor to Drug-Induced Cholestatic Injury.Qiu X, Zhang Y, Liu T, Shen H, Xiao Y, Bourner M, Pratt J, Thompson D, Marathe P, Humphreys WG, Lai Y
    Molecular pharmaceutics, Feb 2016
  • High content analysis assay for prediction of human hepatotoxicity in HepaRG and HepG2 cells.Saito J, Okamura A, Takeuchi K, Hanioka K, Okada A, Ohata T
    Toxicology in vitro, Feb 2016
  • Comparative analysis of 3D culture methods on human HepG2 cells.Luckert C, Schulz C, Lehmann N, Thomas M, Hofmann U, Hammad S, Hengstler JG, Braeuning A, Lampen A, Hessel S
    Archives of toxicology, Feb 2016
  • Hepatic differentiation of human pluripotent stem cells on human liver progenitor HepaRG-derived acellular matrix.Kanninen LK, Porola P, Niklander J, Malinen MM, Corlu A, Guguen-Guillouzo C, Urtti A , Yliperttula ML, Lou YR
    Experimental cell research , Feb 2016
  • Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-Culture with Plated Primary Hepatocytes and HepaRG.Bonn B, Svanberg P, Janefeldt A, Hultman I, Grime KH
    Drug metabolism and disposition, Feb 2016
  • Activation of the constitutive androstane receptor increases the therapeutic index of CHOP in lymphoma treatmentHedrich WD, Xiao J, Heyward S, Zhang Y, Zhang J, Baer MR, Hassan HE, Wang H
    Molecular Cancer Therapeutics, Jan 2016
  • Splicing regulator SLU7 preserves survival of hepatocellular carcinoma cells and other solid tumors via oncogenic miR-17-92 cluster expressionUrastun R, Elizalde M, Azkona M, Latasa MU, Garcia-Irigoyen O, Uriate I, Fernandez-Barrena MG, Vicent S, Alonso MM, Muntané J, Prieto J, Avila MA, Berasain C
    Oncogene, Jan 2016
  • Sp1-mediated ectopic expression of T-cell lymphoma invasion and metastasis 2 in hepatocellular carcinoma.Yen WH, Ke WS, Hung JJ, Chen TM, Chen JS, Sun HS
    Cancer Med, Jan 2016
  • Netrin-1 Protects Hepatocytes Against Cell Death Through Sustained Translation During the Unfolded Protein ResponseLahlali T, Plissonnier ML, Romero-López C, Michelet M, Ducarouge B, Berzal-Herranz A, Zoulim F, Mehlen P, Parent R.
    Cell Mol Gastroenterol Hepatol, Jan 2016
  • Reduced cardiolipin content decreases respiratory chain capacities and increases ATP synthesis yield in the human HepaRG cells.Peyta L, Jarnouen K, Pinault M, Guimaraes C, de Barros JP, Chevalier S, Dumas JF, Maillot F1, Hatch GM1, Loyer P, Servais S
    Biochim Biophys Acta, Jan 2016
  • Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes.Higuchi Y, Kawai K, Kanaki T, Yamazaki H, Chesné C, Guguen-Guillouzo C, Suemizu H
    Hepathology research, Jan 2016
  • Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells.Silva SM, Martinho A, Moreno I, Granadeiro LB, Alves G, Duarte AP, Domingues F, Gallardo E
    Life Sciences, Jan 2016
  • Interferon-? and Tumor Necrosis Factor-? Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.Xia Y, Stadler D, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chou WM, Wettengel JM, Malo A
    Gastroenterology, Jan 2016


  • A human monoclonal antibody against small envelope protein of hepatitis B virus with potent neutralization effect.Wang W, Sun L, Li T, Ma Y, Li J, Liu Y, Li M, Wang L, Li C, Xie Y, Wen Y, Liang M, Chen L
    MAbs, Dec 2015
  • Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cellsSugiyama I, Murayama N, Kuroki A, Kota J, Iwano S, Yamazaki H, Hirota T
    Xenobiotica, Dec 2015
  • A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: application to acetaminophen.Michaut A, Le Guillou D, Moreau C, Bucher S, McGill MR, Martinais S, Gicquel T, Morel I, Robin MA, Jaeschke H, Fromenty B
    Toxicology and Applied Pharmacology, Dec 2015
  • Gemcitabine and Oxaliplatin, but Not Sorafenib or Paclitaxel, Have a Synergistic Effect with Yttrium-90 in Reducing Hepatocellular Carcinoma and Cholangiocarcinoma Cell Line Viability.Edeline J, Coulouarn C, Crouzet L, Pracht M, Lepareur N, Clément B, Garain E,
    Journal of Vascular and Interventional radiology, Dec 2015
  • Biokinetics in repeated-dosing in vitro drug toxicity studiesKramer NI, Di Consiglio E, Blaauboer BJ, Testai E
    Toxicology in vtro, Dec 2015
  • Protein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220Mayati A, Bruyere A, Moreau A, Jouan E, Denizot C, Parmentier Y, Fardel O
    Plos one, Dec 2015
  • Development of an oxygenation culture method for activating the liver-specific functions of HepG2 cells utilizing a collagen vitrigel membrane chamber.Oshikata-Miyazaki A, Takezawa T
    Cytotechnology, Dec 2015
  • In vitro metabolism of the cyanotoxin cylindrospermopsin in HepaRG cells and liver tissue fractionsKittler K, Hurtaud Pessel D, Maul R, Kolrep F, Fessard V
    toxicon, Dec 2015
  • Metabolomics analysis of the toxicity pathways of triphenyl phosphate in HepaRG cells and comparison to oxidative stress mechanisms caused by acetaminophenVan den Eede N, Cuykx M, Rodrigues RM, Laukens K, Neels H, Covaci A5, Vanhaecke T,
    taxicology in vitro, Dec 2015
  • MicroRNA responses to the genotoxic carcinogens aflatoxin B1 and benzo[a]pyrene in human HepaRG cellsMarrone AK, Tryndyak V, Beland FA, Pogribny Ip
    Toxicological Sciences, Nov 2015
  • Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptideOkuyama Dobashi K, Kasai H, Tanaka T, Yasmahita A, Yasumoto J, Chen W, Okamoto T, Maekawa S, Watashi K, Wakita T, Ryo A, Suzuki T, Matsuura Y
    Scientefic reports, Nov 2015
  • Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitroLeite SB, Roosens T, El Taghdouini A, Mannaerts I, Smout AJ, Najimi M, Sokal E, Noor F, Chesne C, van Grunsven LA
    Biomaterials., Nov 2015
  • Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation InvestigatedLassila T, Hokkanen J, Matilla S , Turpeinen M, Tolonen A
    Chemical Research in Technology , Nov 2015
  • Formation of GSH-trapped reactive metabolites in human liver microsomes, S9 fraction, HepaRG-cells, and human hepatocytes.Lassila T, Rousu T, Mattila S, Chesné C, Pelkonen O, Turpeinen M, Tolonen A
    Journal of Pharmaceutical and Biomedical Analysis, Nov 2015
  • A novel cell-based assay for the evaluation of immune- and inflammatory-related gene expression as biomarkers for the risk assessment of drug-induced liver injury.Oda S, Matsuo K, Nakajima A, Yokoi T
    Toxicology Letters, Nov 2015
  • Peroxisome proliferator-activated receptor alpha, PPAR?, directly regulates transcription of cytochrome P450 CYP2C8Thomas M, Winter S, Klumpp B, Turpeinen M, Klein K, Schwab M, Zanger UM
    Frontiers in pharmacology , Nov 2015
  • Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists.Braeuning A, Thomas M, Hofmann U, Vetter S, Zeller E, Petzuch B, Johänning J, Schroth W, Weiss TS, Zanger UM, Schwarz M
    Drug metabolism and disposition, Nov 2015
  • Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells.Li D, Mackowiak B, Brayman TG, Mitchell M, Zhang L, Huang SM, Wang H
    Biochemical pharmacology, Nov 2015
  • MicroRNA hsa-miR-29a-3p modulates CYP2C19 in human liver cells.Yu D, Green B, Tolleson WH, Jin Y, Mei N, Guo Y, Deng H, Pogribny I, Ning B, , , ,
    Biochemicol pharmacology, Nov 2015
  • Regulation of hepatic cardiolipin metabolism by TNF: Implication in cancer cachexiaPeyta L, Jarnouen K, Pinault M, Coulouarn C, Guimaraes C, Goupille C, de Barros JP, Chevalier S, Dumas JF, Maillot F1, Hatch GM1, Loyer P, Servais S
    biochmica biophysica acta, Nov 2015
  • Evaluation of CYP3A4 inhibition and hepatotoxicity using DMSO-treated human hepatoma HuH-7 cellsLiu Y, Flynn TJ, Xia M, Wiesenfeld PL, Ferguson MS
    Cell biology and toxicology, Oct 2015
  • MicroRNA changes, activation of progenitor cells and severity of liver injury in mice induced by choline and folate deficiency.Tryndyak VP, Marrone AK, Latendresse JR, Muskhelishvili L, Beland FA, Pogribny IP, , , , , , ,
    The journal of nutritional biochemistry , Oct 2015
  • Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systemsRodriques RM, Heymans A , De Boe V, Sachinidis A, Chaudhari U , Govaere O, Roskams T, Vanhaecke T, Rogier V, De Kock J
    Texicology Letters, Oct 2015
  • Evaluation of Normalization Methods To Predict CYP3A4 Induction in Six Fully Characterized Cryopreserved Human Hepatocyte Preparations and HepaRG CellsVermet H, Raoust N, Ngo R, Esserméant L, Klieber S, Fabre G, Boulenc X,
    Drug Metab Dispos, Oct 2015
  • Protein kinase C-dependent regulation of human hepatic drug transporter expressionMayati A, Le Vee M, Moreau A, Jouan E, Bucher S, Stieger B, Denizot C, Parmentier Y, Fardel O
    Biochem Pharmacol, Oct 2015
  • Human hepatoma cell lines on gas foaming templated alginate scaffolds for in vitro drug-drug interaction and metabolism studiesStampella A, Rizzitelli G, Donati F, Mazzarino M, Torre X, Bortrè F, Giardi MF, Dentini M, Barbetta A, Massimi M
    Toxicol In Vitro, Oct 2015
  • Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity.Xie Y, Woolbright BL, Kos M, McGill MR, Dorko K, Kumer SC, Schmitt TM, Jaeschke H
    Journal of Clinical and Translational Research, Sep 2015
  • In silico modeling for the prediction of dose and pathway related adverse effects in humans from in vitro repeated-dose studies.Klein S, Maggioni S, Bucher J, Mueller D, Niklas J, Shevchenko V, Mauch K, Heinzle E, Noor F
    Toxicological Sciences, Sep 2015
  • A microfluidically perfused three dimensional human liver modelRennert K, Steinborn S, Groger M, Ungerbock B, Jank AM, Ehgartner J, Nietzsche S, Dinger J, Kiehntopf M, Funke H, Peters F, Lupp A, Gartner C
    Biomaterials, Sep 2015
  • Hepatotoxicity of piperazine designer drugs: Comparison of different in vitro modelsDias-da-Silva D, Arbo MD, Valente MJ, Bastos ML, Carmo H
    Toxicol in vitro, Aug 2015
  • Evaluation of genotoxicity using automated detection of ?H2AX in metabolically competent HepaRG cellsQuesnot N, Rondel K, Audebert M, Martinais S, Glaise D, Morel F, Loyer P, Robin MA,
    Mutagensis, Aug 2015
  • Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human HepatocytesWoolbright B, MacGil MR, Yan H, Jaeschke H, , , , , , , , ,
    Basic Clin Pharmacol Toxicol., Jul 2015
  • Kinetics and dynamics of cyclosporine A in three hepatic cell culture systemsBellwon P, Truisi GL, Bois FY, Wilmes A, Schmitt TM, Savary CC, Parmentier C, Hewitt PG, Schmal O, Josse R, Richert L, Guillouzo A, Mueller SO
    Toxical in vitro, Jul 2015
  • Expression and Functionality of Toll- and RIG-like receptors in HepaRG Cells.Luangsay S, Ait-Goughoulte M, Michelet M, Floriot O, Bonnin M, Gruffaz M, Rivoire M, Fletcher S, Javanbakht H, Lucifora J, Zoulim F, Durantel D
    J Hepatol., Jul 2015
  • HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase.Rivière L, Gerossier L, Ducroux A, Dion S, Deng Q, Michel ML, Buendia MA, Hantz O, Neuveut C
    J Hepatol., Jul 2015
  • Applications of human hepatitis B virus preS domain in bio- and nanotechnology.Toita R, Kawano T, Kang JH, Murata M
    World J Gastroenterol., Jul 2015
  • Hepatic TLR4 Signaling in Obese NAFLDSharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM Jr, Abumrad NN, Flynn CR
    Am J Physiol Gastrointest Liver Physiol., Jun 2015
  • A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalentsMaschmeyer I, Lorenz A, Schimek K, Hasenberg T, Ramme A, Hübner J, Lindner M, Drewell C, Bauer S, Thomas A, Sisoli Sambo N, Sonntag F, Lauster R, Marx U
    Royal Society of Chemical, May 2015
  • The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture.Materne EM, Maschmeyer I, Lorenz AK, Horland R, Schimek KM, Busek M, Sonntag F, Lauster R, Marx U
    J Vis Exp., May 2015
  • Viral Entry of Hepatitis B and D Viruses and Bile Salts Transportation Share Common Molecular Determinants on Sodium Taurocholate Cotransporting PolypeptideYan X, Wang J, Zhu L, Lowrey JJ, Zhang Y, Hou W, Dong J, Du Y
    Lab Chip., May 2015
  • Drug biokinetic and toxicity assessments in rat and human primary hepatocytes and HepaRG cells within the EU-funded Predict-IV project.Mueller SO, Guillouzo A, Hewitt PG, Richert L
    Toxicol In Vitro, May 2015
  • Three-dimensional (3D) spheroid cultures improve the metabolic gene expression profiles of HepaRG cells.Takahashi Y, Hori Y, Yamamoto T, Urashima T, Ohara Y, Tanaka H
    Biosci Rep., May 2015
  • Multiparametric assay using HepaRG cells for predicting drug-induced liver injury.Tomida T, Okamura H, Satsukawa M, Yokoi T, Konno Y
    Toxicol Lett., May 2015
  • Allopurinol and 5-aminosalicylic acid influence thiopurine-induced hepatotoxicity in vitro.Broekman MM, Roelofs HM, Wong DR, Kerstholt M, Leijten A, Hoentjen F, Peters WH, Wanten GJ, de Jong DJ
    Cell Biol Toxicol., May 2015
  • Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.Xie Y, McGill MR, Cook SF, Sharpe MR, Winefield RD, Wilkins DG, Rollins DE, Jaeschke H
    Xenobiotica, Apr 2015
  • Hepatotoxicity of piperazine designer drugs: comparison of different in vitro models.Dias-da-Silva D, Arbo MD, Valente MJ, Bastos ML, Carmo H
    Toxicol. In Vitro, Apr 2015
  • The aryl hydrocarbon receptor-dependent disruption of contact inhibition in rat liver WB-F344 epithelial cells is linked with induction of survivin, but not with inhibition of apoptosis.Svobodová J, Kabátková M, ?merdová L, Brenerová P, Dvo?ák Z, Machala M, Vondrá?ek J
    Toxicology, Apr 2015
  • BK/TD models for analyzing in vitro impedance data on cytotoxicity.Teng S, Barcellini-Couget S, Beaudouin R, Brochot C, Desousa G, Rahmani R, Pery A
    Toxicol Lett., Mar 2015
  • Forced expression of PDX-1 gene makes hepatoma cells to acquire glucose-responsive insulin secretion while maintaining hepatic characteristic.Hashimoto H, Higuchi Y, Kawai K
    Cell Mol Biol, Mar 2015
  • Inflammation-Associated microRNA-130b Downregulates Cytochrome P450 Activities and Directly Targets CYP2C9.Rieger JK, Reutter S, Hofmann U, Schwab M, Zanger UM
    Drug Metabolism Dispos., Mar 2015
  • Prediction of Gestational Age-Dependent Induction of In Vivo Hepatic CYP3A Activity Based on HepaRG Cells and Human Hepatocytes.Zhang Z, Farooq M, Prasad B, Grepper S, Unadkat JD
    Drug Metabolism Dispos., Mar 2015
  • Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitisDubuquoy L, Louvet A, Lassailly G, Truant S, Boleslawski E, Artru F, Maggiotto F, Gantier E, Buob D, Leteurtre E , Cannesson A, Dharancy S, Moreno C, Pruvot FR, Bataller R, Mathurin P
    Hepatology, Mar 2015
  • Interleukin 6 inhibits HBV entry through NTCP down regulation.Bouezzedine F, Fardel O, Gripon P
    Virology, Mar 2015
  • Characterizing the mechanism of thiazolidinedione-induced hepatotoxicity: an in vitro model in mitochondria.Hu D, Wu CQ, Li ZJ, Liu Y, Fan X, Wang QJ, Ding RG
    Toxicol Appl Pharmacol., Mar 2015
  • Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells.Buick JK, Moffat I, Williams A, Swartz CD, Recio L, Hyduke DR, Li HH, Fornace AJ Jr, Aubrecht J, Yauk CL
    Environ Mol Mutagen., Mar 2015
  • Aberrant DNA methylation of imprinted loci in hepatocellular carcinoma and after in vitro exposure to common risk factors.Lambert MP, Ancey PB, Esposti DD, Cros MP, Sklias A, Scoazec JY, Durantel D, Hernandez-Vargas H, Herceg Z
    Clin Epigenetics, Feb 2015
  • Comparative localization and functional activity of the main hepatobiliary transporters in HepaRG cells and primary human hepatocytes.Bachour-El Azzi P, Sharanek A, Burban A, Li R, Le Guével R, Abdel-Razzak Z, Stieger B, Guguen-Guillouzo C, Guillouzo A
    Toxicol Sci., Feb 2015
  • Cell-specific biotransformation of benzophenone-2 and bisphenol-S in zebrafish and human in vitro models used for toxicity and estrogenicity screening.Le Fol V, Ait-Aissa S, Cabaton N, Dolo L, Grimaldi M, Balaguer P, Perdu E, Debrauwer L, Brion F, Zalko D
    Environ Sci Technol., Feb 2015
  • Sgo1 is a potential therapeutic target for hepatocellular carcinoma.Wang LH, Yen CJ, Li TN, Elowe S, Wang WC, Wang LH
    Oncotarget., Jan 2015
  • Detection of main metabolites of XLR-11 and its thermal degradation product in human hepatoma HepaRG cells and human urine.Kanamori T, Kanda K, Yamamuro T, Kuwayama K, Tsujikawa K, Iwata YT, Inoue T
    Drug Test Anal., Jan 2015
  • Understanding the biokinetics of ibuprofen after single and repeated treatments in rat and human in vitro liver cell systems.Truisi GL, Consiglio ED, Parmentier C, Savary CC, Pomponio G, Bois F, Lauer B, Jossé R, Hewitt PG, Mueller SO, Richert L, Guillouzo A, Testai E
    Toxicology Lett., Jan 2015
  • Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human LiverHuch M, Gehart H, Boxtel R, Hamer K, Blokzijl K, Verstegen M, Ellis E, Wenum M, Fuchs S, de Ligt J, van de Wetering M, Sasaki N, Boers S, Kemperman H, de Jonge J, N.M. Ijzermans J, Nieuwenhuis E, Hoekstra R, Strom S, Vries R, van der Laan L, Cuppen E...
    Cells, Jan 2015
  • Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period.Savary CC, Jiang X, Aubry M, Jossé R, Kopp-Schneider A, Hewitt P, Guillouzo A
    Toxicology In Vitro, Jan 2015


  • In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatments.Pomponio G, Savary C, Parmentier C, Bois F, Guillouzo A, Romanelli L, Richert L, Di Consiglio E, Testai E
    Toxicol In Vitro., Dec 2014
  • Human HepaRG cells can be cultured in hanging-drop plates for cytochrome P450 induction and function assays Murayama N, Usui T, Slawny N, Chesné C, Yamazaki H
    Drug Metabolism Letters, Dec 2014
  • Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor a/y ligand LT175Piemontese L, Fracchiolla G, Carrieri A, Parente M, Laghezza A, Carbonara G, Sblano S , Tauro M, Gilardi F, Tortorella P, Lavecchia A, Crestani M, Desvergne B, Loiodice F
    Journal of Medicinal Chemistry, Dec 2014
  • Expression and characterization of myristoylated preS1-conjugated nanocages for targeted cell delivery.Murata M, Piao JS, Narahara S, Kawano T, Hamano N, Kang JH, Asai D, Ugawa R, Hashizume M
    Protein Expr Purif., Dec 2014
  • HepaRG culture in tethered spheroids as an in vitro three-dimensional model for drug safety screeningWang Z, Luo X, Anene-Nzelu C, Yu Y, Hong X, Singh N, Xia L, Liu S, Yu H
    Journal of applied toxicology, Dec 2014
  • Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways.Liu Y, Li J, Chen J, Wang W, Du X, Song W, Zhang W, Lin L, Yuan Z
    J Virol., Dec 2014
  • Activating and inhibitory functions of WNT/B-catenin in the induction of cytochromes P450 by nuclear receptors in HepaRG cellsThomas M, Bayha C, Vetter S, Hofmann U, Schwarz M, Zanger UM, Braeuning A
    MolPharmacol, Dec 2014
  • Organocatalysis Paradigm Revisited: Are Metal-free Catalysts really Harmless?Nachtergael A, Coulembier O, Dubois P, Helvenstein M, Duez P, Blankert B, Mespouille L
    Biomacromolecules, Dec 2014
  • A Systematic Comparison of the Impact of Inflammatory Signaling on ADME Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells.Klein M, Thomas M, Hofmann U, Seehofer D, Damm G, Zanger UM
    Drug Metab Dispos., Dec 2014
  • Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposure.Broeders JJ, Parmentier C, Truisi GL, Jossé R, Alexandre E, Savary CC, Hewitt PG, Mueller SO, Guillouzo A, Richert L, van Eijkeren JC, Hermens JL, Blaauboer BJ
    Toxicol. In Vitro, Dec 2014
  • Metoronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes.Kudo T, Endo Y, Taguchi R, Yatsu M, Ito K
    Xenobiotica, Dec 2014
  • In vitro-to-in vivo correlation of the skin penetration, liver clearance and hepatotoxicity of caffeine.Gajewska M, Paina A, Sala Benito JV, Burton J, Worth A, Urani C, Briesen H, Schramm KW
    Food Chem Toxicol., Dec 2014
  • Intracellular accumulation of subviral HBsAg particles and diminished Nrf2 activation in HBV genotype G expressing cells lead to an increased ROI level.Peiffer KH, Akhras S, Himmelsbach K, Hassemer M, Finkernagel M, Carra G, Nuebling M, Chudy M, Niekamp H, Glebe D, Sarrazin C, Zeuzem S, Hildt E
    Journal of Hepatology, Dec 2014
  • The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury.McGill MR, Du K, Xie Y, Bajt ML, Ding WX, Jaeschke H
    Xenobiotica, Nov 2014
  • Biotransformation in vitro: An essential consideration in the quantitative in vitro-to-in vivo extrapolation (QIVIVE) of toxicity dataWilk-Zasadna I,Bernasconi C, Pelkonen O, Coecke S
    Toxicology, Nov 2014
  • Live spheroid formation recorded with light sheet-based fluorescence microscopy.Pampaloni F, Richa R, Ansari N, Stelzer EH.
    Methods Mol Biol., Nov 2014
  • A trial study on proteomics fingerprint analysis of HepaRG cells by FD-LC-MS/MSKazuhiro Imai, Katsunori Nakata, Tomoko Ichibangase, Ryoichi Saitoh , Masaki Ishigai
    Analyst, Nov 2014
  • Bioartificial livers in vitro and in vivo: tailoring biocomponents to the expanding variety of applicationsWenum M, Chamuleau RA, Gulik T, Siliakus A, Seppen J, Hoekstra H
    Expert Opinion, Nov 2014
  • HepaRG cells as human relevant in vitro model to study the effects of inflammatory stimuli on Cytochrome P450 isoenzymesRubin K, Janefeldt A, Andersson L, Berke Z, Grime K, Andersson TB
    Drug Metab Dispos. , Nov 2014
  • Regulation of Hepatic Drug Transporter Activity and Expression by Organochlorine PesticidesBucher S, Le Vee M, Jouan E, Fardel O
  • Alisporivir Inhibition of Hepatocyte Cyclophilins Reduces HBV Replication and Hepatitis B Surface Antigen Production Phillips S, Chokshi S, Chatterji U, Riva A, Bobardt M, Williams R, Gallay P, V. Naoumov N
    Gastroenterology, Oct 2014
  • Expression of Stress-Dependent Genes in Hepatocytes Spheroids after Cisplatin Treatment.Rusanov AL, Pul'kova NV, Klonova MG, Fomicheva KA, Kozhin PM, Sevast'yanova MA, Shkurnikov MY
    Bull Exp Biol Med., Sep 2014
  • Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells.Tobwala S, Khayyat A, Fan W, Ercal N
    Exp Biol Med, Sep 2014
  • Reversible immortalization of human hepatocytes mediated by retroviral transfer and site-specific recombinationMeng FY, Liu L, Yang FH, Li CY, Liu J, Zhou P
    Journal of Gastroenterology, Sep 2014
  • Diversified expression of aryl hydrocarbon receptor dependent genes in human laryngeal squamous cell carcinoma cell lines treated with ?-naphthoflavone.Brauze D, Fijalkiewicz K, Szaumkessel M, Kiwerska K, Bednarek K, Rydzanicz M, Richter J, Grenman R, Jarmuz-Szymczak M
    Toxicol Lett., Sep 2014
  • Inhibition of Cytochrome P450 2C9 Expression and Activity In Vitro by Allyl Isothiocyanate.Lim YP, Chen WC, Cheng CH, Ma WC, Lin YH, Chen CY, Hung DZ, Chen JJ, Yokoi T, Nakajima M, Chen CJ
    Planta Med, Sep 2014
  • HepaRG cell line as an in vitro model for screening drug-drug interactions mediated by metabolic induction: amiodarone used as a model substance.Ferreira A, Rodrigues M, Silvestre S, Falcão A, Alves G
    Toxicol In Vitro., Aug 2014
  • High Content Imaging and Analysis Enables Quantitative In Situ Assessment of CYP3A4 using Cryopreserved Differentiated HepaRG Cells.Ranade AR, Melinda S. Wilson, Amy M. McClanahan, Andrew J. Ball
    -, Aug 2014
  • HepaRG microencapsulated spheroids in DMSO-free culture: novel culturing approaches for enhanced xenobiotic and biosynthetic metabolism.Rebelo SP, Costa R, Estrada M, Shevchenko V, Brito C, Alves PM
    Arch Toxicol., Aug 2014
  • Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells.Dubois-Pot-Schneider H, Fekir K, Coulouarn C, Glaise D, Aninat C, Jarnouen K, Le Guével R, Kubo T, Ishida S, Morel F, Corlu A
    Hepatology, Aug 2014
  • Dual-colour fluorescence imaging to monitor CYP3A4 and CYP3A7 expression in human hepatic carcinoma HepG2 and HepaRG cells.Tsuji S, Kawamura F, Kubiura M, Hayashi A, Ohbayashi T, Kazuki Y, Chesné C, Oshimura M, Tada M
    PloS One, Aug 2014
  • Nicotine, cotinine, and β-nicotyrine inhibit NNK-induced DNA-strand break in the hepatic cell line HepaRG.Ordonez P, Sierra AB, Camacho OM, Baxter A, Banerjee A, Waters D, Minet E
    Toxicol In Vitro, Jul 2014
  • Antioxidant potential of Sutherlandia frutescens and its protective effects against oxidative stress in various cell cultures.Tobwala S, Fan W, Hines CJ, Folk WR, Ercal N
    BMC Complement Altern Med., Jul 2014
  • Liver X receptor α (LXRα /NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4 αChen KT, Pernelle K, Tsai YH, Wu YH, Hsieh JY, Liao KH, Guguen-Guillouzo C, Wang HW
    J Hepatol., Jul 2014
  • Rapid Prototyping of Chitosan-Coated Alginate Scaffolds Through the Use of a 3D Fiber Deposition Technique.Cristina Colosia, Marco Costantinia, Roberta Latinia, Serena Ciccarellia, Alessandra Stampellac, Andrea Barbettaa, Mara Massimib, Laura Conti Devirgiliisc, Mariella Dentini
    J Mat Chem, Jul 2014
  • Antidiabetic effects of the Cimicifuga racemosa extract Ze 450 in vitro and in vivo in ob/ob mice.Moser C, Vickers SP, Brammer R, Cheetham SC, Drewe J
    Phytomedicine, Jul 2014
  • Impact of Inflammation on Chlorpromazine-induced Cytotoxicity and Cholestatic Features in HepaRG Cells.Bachour-El Azzi P, Sharanek A, Abdel-Razzak Z, Antherieu S, Al-Attrache H, Savary C, Lepage S, Morel I, Labbe G, Guguen-Guillouzo C, Guillouzo A
    Drug Metab Dispos., Jul 2014
  • Strategies to Inhibit Entry of HBV and HDV Into Hepatocytes.Urban S, Bartenschlager R, Kubitz R, Zoulim F
    Gastroenterology, Jul 2014
  • Detection of Dichlorvos Adducts in a Hepatocyte Cell Line.Bui-Nguyen TM, Dennis WE, Jackson DA, Stallings JD, Lewis JA
    J Proteome Res., Jun 2014
  • Different Dose-Dependent Mechanisms are Involved in Early Cyclosporine A-Induced Cholestatic Effects in HepaRG Cells.Sharanek A, Bachour-El Azzi P, Al-Attrache H, Savary CC, Humbert L, Rainteau D, Guguen-Guillouzo C, Guillouzo A
    Toxicol Sci., Jun 2014
  • Reflection Coefficient S11 Related Measurement System for Label-Free Cell Seeding Analysis and Drug Testing in a Three-Dimensional (3D) Cell Culture Model.Lornejad-Schäfer MR, Hilber W, Schäfer C
    J Biosciences, Jun 2014
  • Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes.Sjogren AK, Liljevald M, Glinghammar B, Sagemark J, Li XQ, Jonebring A, Cotgreave I, Brolén G, Andersson TB
    Arch Toxicol, Jun 2014
  • Effect and mechanisms of curdlan sulfate on inhibiting HBV infection and acting as an HB vaccine adjuvant.Li P, Tan H, Xu D, Yin F, Cheng Y, Zhang X, Liu Y, Wang F
    Carbohydr Polym, Jun 2014
  • Testing chemical carcinogenicity by using a transcriptomics HepaRG-Based model?Doktorova T, Yildirimman R, Ceelen L, Vilardell M, Vanhaecke T, Vinken M, Ates G, Heymans A, Gmuender H, Bort R, Corvi R, Phrakonkham P, Li R
    EXCLI Journal, Jun 2014
  • Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.Xie Y, McGill MR, Dorko K, Kumer SC, Schmitt TM, Forster J, Jaeschke H
    Toxicol Appl Pharmacol., Jun 2014
  • Interactions of Endosulfan and Methoxychlor Involving CYP3A4 and CYP2B6 in Human HepaRG Cells.Savary CC, Josse R, Guillet F, Bruyere A, Robin MA, Guillouzo A
    Drug Metab Dispo, May 2014
  • Splicing regulator SLU7 is essential for maintaining liver homeostasisElizalde M,Urtasun R,Akzona M,Latasa MU,Goni S,Garcia-Irigoyen O,Uriarte I,Segura V,Collantes M,Di Scala M,Lujambio A,Prieto J,Avila MA, Berasain C
    J Clinical Investigation, May 2014
  • Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells.Dianat N, Dubois-Pot-Schneider H, Steichen C, Desterke C, Leclerc P, Raveux A, Combettes L, Weber A, Corlu A, Dubart-Kupperschmitt A
    Hepatology, Apr 2014
  • Differentiation of liver progenitor cell line to functional organotypic cultures in 3D nanofibrillar cellulose and hyaluronan-gelatin hydrogels.Malinen MM, Kanninen LK, Corlu A, Isoniemi HM, Lou YR, Yliperttula ML, Urtti AO
    Biomaterials, Apr 2014
  • Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-specific Entry into Hepatocytes.Ni Y, Lempp FA, Mehrle S, Nkongolo S, Kaufman C, Fälth M, Stindt J, Königer C, Nassal M, Kubitz R, Sültmann H, Urban S
    Gastroenterology, Apr 2014
  • Comparative study of the effects of anti-tuberculosis drugs and antiretroviral drugs on CYP3A4 and P-glycoprotein.Horita Y, Doi N
    Antimicrob Agents Chemother, Mar 2014
  • Evaluation of Impedance-Based Label-Free Technology as a Tool for Pharmacology and Toxicology InvestigationsAtienzar FA, Gerets H, Tilmant K, Toussaint G, Dhalluin S
    Biosensors, Mar 2014
  • Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B virus cccDNAJulie Lucifora, Yuchen Xia, Florian Reisinger, Ke Zhang, Daniela Stadler, Xiaoming Cheng, Martin F. Sprinzl, Herwig Koppensteiner, Zuzanna Makowska, Tassilo Volz, Caroline Remouchamps, Wen-Min Chou, Wolfgang E. Thasler, Norbert Hüser, David Durantel, T. J
    Science AAAS, Mar 2014
  • Menthol reduces the anticoagulant effect of warfarin by inducing cytochrome P450 2C expression.Hoshino M, Ikarashi N, Tsukui M, Kurokawa A, Naito R, Suzuki M, Yokobori K, Ochiai T, Ishii M, Kusunoki Y
    Eur J Pharm Sci, Mar 2014
  • Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450.Yajima K, Uno Y, Murayama N, Uehara S, Shimizu M, Nakamura C, Iwasaki K, Utoh M, Yamazaki H
    Drug metab dispo, Feb 2014
  • NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry.Watashi K, Urban S, Li W, Wakita T
    Int J Mol Sci., Feb 2014
  • Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures.Dembélé L, Franetich JF, Lorthiois A, Gego A, Zeeman AM, Kocken C, Le Grand R, Dereuddre-Bosquet N, van Gemert GJ, Sauerwein R
    Nat med, Feb 2014
  • Adverse outcome pathway-based screening strategies for an animal-free safety assessment of chemicals.Landesmann B, Mennecozzi M, Berggren E, Whelan M
    Altern Lab Anim, Feb 2014
  • PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells.Rogue A, Anthérieu S, Vluggens A, Umbdenstock T, Claude N, Moureyre-Spire C, Weaver R, Guillouzo A
    Nature Med, Feb 2014
  • CYP3A4 activity reduces the cytotoxic effects of okadaic acid in HepaRG cells.Kittler K,Fessard V,Maul R,Hurtaud-Pessel D
    Arch Toxicol., Feb 2014
  • Thalidomide Increases Human Hepatic Cytochrome P450 3A Enzymes by Direct Activation of Pregnane X Receptor.Murayama N, Beuningen R, Suemizu H, Guguen-Guillouzo C, Shibata N, Yajima K, Utoh M, Chesné C, Yamazaki H, Shimizu M
    Chem Res Toxicol, Jan 2014
  • Absence of in vitro genotoxicity potential of the mycotoxin deoxynivalenol in bacteria and in human TK6 and HepaRG cell lines.Takakura N, Nesslany F, Fessard V, Hegarat LL
    Food Chem Toxicol., Jan 2014
  • Viral Entry of Hepatitis B and D Viruses and Bile Salts Transportation Share Common Molecular Determinants on Sodium Taurocholate Cotransporting Polypeptide Yan H, Peng B, Liu Y, Xu G, He W, Ren B, Jing Z, Sui J, Li W
    J Virol, Jan 2014
  • Performance of comet and micronucleus assays in metabolic competent HepaRG cells to predict in vivo geno toxicity.Le Hegarat L, Mourot A, Huet S, Vasseur L, Camus S, Chesne C, Fessard V.
    Toxcixol SCI, Jan 2014
  • Human Placental Lactogen Induces CYP2E1 Expression Via PI 3-kinase Pathway in Female Human Hepatocytes.Lee JK, Chung HJ, Fischer L, Fischer J, Gonzalez FJ, Jeong H.
    Drug Metab Dispos., Jan 2014
  • Regulation of Hepatic Drug Transporter Activity and Expression by Organochlorine Pesticides.Bucher S, Le Vee M, Jouan E, Fardel O
    J Biochem Mol Toxicol, Jan 2014


  • Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter NTCP.Watashi K, Sluder A, Daito T, Matsunaga S, Ryo A, Nagamori S, Iwamoto M, Nakajima S, Tsukuda S, Borroto-Esoda K, Sugiyama M, Tanaka Y, Kanai Y
    Hepatology, Dec 2013
  • Cellular impact of combinations of endosulfan, atrazine, and chlorpyrifos on human primary hepatocytes and HepaRG cells after short and chronic exposures.Nawaz A, Razpotnik A, Rouimi P, de Sousa G, Cravedi JP, Rahmani R
    Cell Biol Toxicol, Dec 2013
  • Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP.Iwamoto M, Watashi K, Aly HH, Fukasawa M, Fujimoto A, Suzuki R, Aizaki H, Ito T, Koiwai O, Kusuhara H, Wakita T
    Biochem Biophys Res Commun, Dec 2013
  • Impact of isomalathion on malathion cytotoxicity and genotoxicity in human HepaRG cells.Josse R, Sharanek A, Savary C, Guillouzo A
    Chem Biol Interact, Dec 2013
  • Monoclonal antibodies to various epitopes of HBs antigen inhibit HBV infection.Golsaz Shirazi F, Mohammadi H, Amiri MM, Singethan K, Xia Y, Bayat AA, Bahadori M, Rabbani H, Jeddi-Tehrani M, Protzer U, Shokri F
    J Gastroenterol Hepatol, Dec 2013
  • A bispecific antibody against two different epitopes on hepatitis B surface antigen has potent hepatitis B virus neutralizing activity.Tan W,Meng Y,Li H,Chen Y,Han S,Zeng J,Huang A,Li B,Zhang Y,Guo Y
    MAbs., Nov 2013
  • Cyclosporin A inhibits Hepatitis B and Hepatitis D Virus entry by Cyclophilin-independent interference with the NTCP receptor.Nkongolo S, Lempp FA, Ni Y, Kaufman C, Lindner T, Esser-Nobis K, Lohmann V, Mier W, Mehrle S, Urban S
    J Hepatol, Nov 2013
  • Studies on the Role of Metabolic Activation in Tyrosine Kinase Inhibitor (TKI)-dependent Hepatotoxicity: Induction of CYP3A4 Enhances the Cytotoxicity of Lapatinib in HepaRG Cells.Hardy KD, Wahlin MD, Papageorgiou I, Unadkat J, Rettie AE, Nelson SD
    Drug metab Dispos, Nov 2013
  • 3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies.Mueller D., Krämer L., Hoffmann E., Klein S., Noor F.
    Toxicolgy in Vitro, Oct 2013
  • A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture.Wagner I, Materne EM, Brincker S, Süssbier U, Frädrich C, Busek M, Sonntag F, Sakharov DA,Trushkin EV, Tonevitsky AG
    Lab Chip, Sep 2013
  • Long-term maintenance of HepaRG cells in serum-free conditions and application in a repeated dose study.Klein S, Mueller D, Schevchenko V, Noor F.
    J Appl Toxicol., Sep 2013
  • Profiling the Impact of Medium Formulation on Morphology and Functionality of Primary Hepatocytes in vitro.Nelson LJ, Treskes P, Howie AF, Walker SW., Hayes PC, Prelvis JN
    Scientific Reports, Sep 2013
  • The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice.Higuchi Y, Kawai K, Yamazaki H, Nakamura M, Bree F, Guguen-Guillouzo C, Suemizu H
    Xenobiotica, Sep 2013
  • Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells.Le Vee M, Noel G, Jouan E, Stieger B, Fardel O
    Toxicology in vitro, Sep 2013
  • Iron-mediated effect of alcohol on hepatocyte differentiation in HepaRG cells.Do TH, Gaboriau F, Cannie I, Batusanski F, Ropert M, Moirand R, Brissot P, Loreal O, Lescoat G
    Chem biol interact, Sep 2013
  • Interleukin-1 and tumor necrosis factor-alpha trigger restriction of hepatitis B virus infection via a cytidine deaminase AID.Watashi K, Liang G, Iwamoto M, Marusawa H, Uchida N, Daito T, Kitamura K, Maramatsu M, Ohashi H, Kiyohara T, Suzuki R, Li J, Tong S
    J Biol Chem, Sep 2013
  • Evaluation of Normalization Strategies Used in Real-Time Quantitative PCR Experiments in HepaRG Cell Line Studies.Ceelen L, De Craene J, De Spiegelaere W
    Clin Chem, Sep 2013
  • Metabolic characterization of cell systems used in in vitro toxicology testing: Lung cell system BEAS-2B as a working example.Garcia-Canton C, Minet E, Anadon A, Meredith C
    Toxicol In vitro, Sep 2013
  • Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J
    Arch Toxicol., Aug 2013
  • In vitro drug metabolism testing using blood-monocyte derivatives.Gomez-Icazbalceta G, Gonzalez Sanchez I, Moreno J, Cerbon MA, Cervantes A
    Expert Opin Drug Metab Toxicol, Aug 2013
  • Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis.Kienhuis AS, Vitins AP, Pennings JL, Pronk TE, Speksnijder EN, Roodbergen N, Van Delft JH, Luijten M, Van der ven LT
    Toxicol Lett, Aug 2013
  • Comparative Proteomics Reveals Novel Components at the Plasma Membrane of Differentiated HepaRG Cells and Different Distribution in Hepatocyte- and Biliary-Like Cells.Petrareanu C, Macovei A, Sokolawska, Woods AG, Lazar C, Radu GL, Darie CC, Branza-Nichita N
    PloS One, Aug 2013
  • Rapid fabricating technique for multi-layered human hepatic cell sheets by forceful contraction of the fibroblast monolayer.Sakai Y, Koike M, Hasegawa H, Yamnouchi K, Soyama A, Takatsuki M, Kuroki T, Oshaki K, Okano T, Egushi S
    PloS One, Jul 2013
  • Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes.Jetten MJ, Kleinjans JC, Claessen SM, Chesné C, Van Deft JH
    Toxicol in vitro, Jul 2013
  • Degradable and biocompatible nanoparticles decorated with cyclic RGD peptide for efficient drug delivery to hepatoma cells in vitro.Loyer P, Bedhouche W, Huang ZW, Cammas-Marion S
    Int J Pharm, Jun 2013
  • Regulation of hepatitis B virus infection by Rab5, Rab7, and the endolysosomal compartment.Macovei A, Petrareanu C, Lazar C, Florian P, Branza-Nichita N
    J virol, Jun 2013
  • Increased hepatic functionality of the human hepatoma cell line HepaRG cultured in the AMC bioreactor.Nibourg G, Hoekstra R, van der Hoeven T., Ackermans M, Hakvoort TB, van Gulik T, Chamuleau R
    Int J Biochem Cell Biol., Jun 2013
  • Highly efficient Sirna and Gene transfer into Hepatocyte-like HepaRG Cells and primary human Hepatocytes : New Means for Drug Metabolism and Toxicity Studies.Laurent V, Glaise D, Nubel T, Gilot D, Corlu A, Loyer P
    Methods Mol Biol, May 2013
  • Characterization of the anti-HBV activity of HLP1-23, a human lactoferrin-derived peptide.Florian P, Macovei A, Lazar C, Milac AL, Sokolowska I, Darie CC, Evans RW, Roseanu A, Branza-Nichita N
    J med Virol, May 2013
  • Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator.Watanabe K, Sakurai K, Tsushiya Y, Yamazoe Y, Yoshinari K
    Biochem Pharmacol, May 2013
  • Replication-competent infectious hepatitis B virus vectors carrying substantially sized transgenes by redesigned viral polymerase translation.Wang z, Wu L, Cheng X, Liu S, Li B, Li H, Kang F, Wang J, Xia H, Ping C, Nassal M, Sun D
    PLoS One, Apr 2013
  • Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling.Driessen M, Kienhuis AS, Pennings JL, Pronk TE, van de Brandhof EJ, Roodbergen M, Spaink HP, van de Water B, van der Ven LT
    Arch Toxicol, Apr 2013
  • Comparison of human Hepatoma hepaRG Cells with Human and Rat Hepatocytes in Uptake transport assays in order to Predict a risk of Drug Induced Hepatotoxicity.Szabo M, Veres Z, Baranyai Z, Kjakab F, Jemnitz K
    PloS One, Mar 2013
  • Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes.Caron S, Samanez CH, Dehondt H, Ploton M, Briand O, Lien F, Dorchies E, Dumont J, Postic C, Cariou B, Lefebvre P, Staels B
    Mol cell biol, Mar 2013
  • Metabolomic signatures in lipid-loaded HepaRGs reveal pathways involved in steatotic progression.Brown M, Compton S, Milburn M, Lawton K, Cheatham B
    Obesity , Mar 2013
  • Proteoglycans Act as Cellular Hepatitis Delta Virus Attachment Receptors.lamas longarela O, Schmidt TT, Schoneweis K, Romeo R, Wedemeyer H, Urban S, Schulze A
    PloS One, Mar 2013
  • Ezetimibe blocks hepatitis B virus infection after virus uptake into hepatocytes.Lucifora J, Esser K, Protzer U
    Antiviral Res., Feb 2013
  • Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models.Doktorova TY, Yildirimman R, Vinken M, Vilardell M, Vanhaecke T, Gmuender H, Bort R, Brolen G, Holmgren G, Li R, Vhesne C, Van Deft J, Kleinjans J
    Carcinogenis, Feb 2013
  • Induction of Hepatic CYP3A Enzymes by Pregnancy-Related Hormones: Studies in Human Hepatocytes and Hepatic Cell Lines.Papageorgiou I, Grepper S, Unadkat Jd
    Drug metab Dispos, Feb 2013
  • 3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies.Gunness P, Mueller D, Shevshenko V, Heinzle E, Ingelmann-Sundberg M, Noor F
    Toxicological Sciences, Feb 2013
  • The HepaRG cell line : a valuable in vitro tool hepatitis virus infection studies.Ceelen L, Lieveld M, Forsyth R, vinken M
    Hepatol Int, Jan 2013
  • In vitro biokinetics of chlorpromazine and the influence of different dose metrics on effect concentrations for cytotoxicity in Balb/c 3T3, Caco-2 and HepaRG cell cultures.Broeders JJ, Blaauboer BJ, Hermens JL
    Toxicological Sciences, Jan 2013
  • Truncated Active Human Matrix Metalloproteinase-8 Delivered by a Chimeric Adenovirus-Hepatitis B Virus Vector Ameliorates Rat Liver CirrhosisLiu J, Cheng X, Guo Z, Wang Z, Li D, Kang F, Li H, Li B, Cao Z, Nassal M, Sun D
    PLOS one, Jan 2013
  • Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells.Cuconati A, Mills C, Goddard C, Zhang X, Yu W, Guo H, Xu X, Block TM
    PloS One, Jan 2013
  • Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes.Le Vee M, Jouan E, Stieger B, Fardel O
    Eur J Pharm Sci., Jan 2013


  • Assessment of an automated in vitro basal cytotoxicity test system based on metabolically-competent cells.Rodrigues RM, Bouhifd M, Bories G, Sacco MG, Gribaldo L, Fabbri M, Coecke S, Whelan MP
    Toxicol In vitro, Dec 2012
  • Substantial Phase 1 and Phase 2 Drug Metabolism and Bile Acid Production of HepaRG Cells in a Bioartificial Liver in Absence of Dimethyl Sulfoxide.Hoekstra R, Nibourg Ga, Van der Hoeven TV, Plomer G, Sppen J, Ackermans MT, CamusS, Kulik W, van Gulik TM, Oude Elferink RP, Chalumeau RA
    Drug metab Dispos, Dec 2012
  • Effects of acute-liver-failure-plasma exposure on hepatic functionality of HepaRG-AMC-Bioartificial Liver.Nibourg GA, Hoekstra R, Van der Hoeven TV, Ackermans MT, Hakvoort TB, Van Gulik TM, Chamuleau RA
    Liver Int., Dec 2012
  • Myristoylated preS1-domain of the hepatitis B virus L-protein mediates specific binding todifferentiated hepatocytes.Meier A, Mehrle S, Weiss Ts, Mier W, Urban S
    Hepatology , Dec 2012
  • Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease.Derdak Z, Villegas KA, Harb R, Wu AM, Sousa A, Wands JR
    J Hepatol, Dec 2012
  • Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus.Yan H, Zhong G, Xu G, He W, jing Z, Gao Z, Huang Y, Qi Y, Peng B, Wang H, Fu l, Song M, Chen P
    eLife, Nov 2012
  • Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human heparg cells.Anthérieu S, Azzi PB, Dumont J, Abdel-Razzak Z, Guguen-Guillouzo C, Fromenty B, Robin MA, Guillouzo A
    Hepatology, Nov 2012
  • New models of hepatitis E virus replication in human and porcine hepatocyte cell lines.Rogee S, Talbot N, Caperna T, Bouquet J, Barnaud E, Pavio N
    J Gen Virol., Nov 2012
  • Modulation of ethanol effect on hepatocyte proliferation by polyamines.Do TH, Gaboriau F, Morel I, Lepage S, Cannie I, Loréal O, Lescoat G
    Amino Acids, Oct 2012
  • Functional consequences of WNT3-Frizzled7- mediated signaling in non-transformed hepatic cells.Nambotin SB, Tomimaru Y, Merle P, Wands JR, Kim M
    Oncogenesis, Oct 2012
  • The effect of rat acute-liver-failure plasma on HepaRG cells.Hoekstra R, Nibourg GA, Hoeven TV, Ackermans MT, Hakvoort TB, Gulik TM, Elferink RP, Chamuleau RA
    Int J Artif Organs, Sep 2012
  • Preservation, induction or incorporation of metabolism into the in vitro cellular system.Pelkonen O, Turpeinen M, Hakkola J, Abass K, Pasanen M, Raunio H, Vähäkangas K
    Tox In Vitro, Aug 2012
  • Expression and transport function of drug uptake transporters in differentiated HepaRG cells.Kotani N, Maeda K, Debori Y, Camus S, Li R, Chesne C, Sugiyama Y
    Mol Pharmacol., Aug 2012
  • Investigation of ifosfamide nephrotoxicity induced in a liver kidney co-culture biochip.Choucha-Snouber L, Aninat C, Grsicom L, Madalinski G, Brochot C, Poleni PE, Razan F, Guillouzo CG, Legallais C, Corlu A, Leclerc E
    Biotechnol Bioeng., Aug 2012
  • Proteomic analysis of plasma membranes isolated from undifferentiated and differentiated HepaRG cells.Sokolowska I, Dorobantu C, Woods AG, Macovei A, Branza-Nichita N, Darie CC
    Proteome Sci., Aug 2012
  • Analysis of the epitope and neutralizing capacity of human monoclonal antibodies.Tajiri K, Ozawa T, Jin A, Tokimitsu Y, Minemura M, Kishi H, Sugiyama Y, Muraguchi A
    Antiviral Research, Jul 2012
  • Characterization of the Host Factors Required for Hepadnavirus Covalently Closed Circular (ccc) DNA Formation.Guo H, Xu C, Zhou T, Block TM, Guo JT
    Plos One, Jul 2012
  • 3D HepaRG Model as an attractive tool for toxicity testing.Leite SB, Wilk-Zasadna I, Zaldivar Comenges JM, Airola E, Reis-Fernandes MA, Mennecozzi M, Guguen-Guillouzo C, Chesne C, Gouillou C, Alves PM, Coecke S
    Toxicol Sci., Jul 2012
  • Evaluation of Organic Anion-Transporting Polypstide 1B1 and CYP3A4 activities in primary human hepatocytes and HepaRGcells cultured in a dynamic three-dimensional bioreactor system.Ulvestad M, Darnell M, Molden E, Ellis E, Asberg A, Andersson TB
    J Pharmacol Exp Ther., Jul 2012
  • In vitro evaluation of major in vivo drug metabolic pathways using primary human hepatocytes and HepaRG cells in suspension and in a dynamic three-dimensional bioreactor system.Darnell MH, Ulvestad M, Ellis E, Weidolf L, Andersson TB
    J Pharmacol Exp Ther., Jul 2012
  • Nanofibrillar cellulose hydrogel promotes three-dimensional liver cell culture.Bhattacharya M, Malinen MM, Lauren P, Lou YR, Kuisma SW, Kanninen L, Lille M, Corlu A, Guguen-Guillouzo C, Ikkala O, Laukkanen A, Urtti A, Yliperttula M
    J Control Release, Jul 2012
  • The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in human.Andersson TB, Kanebratt KP, Kenna JG
    Expert Opin Drug Metab Toxicol, Jul 2012
  • Proliferative human cell sources applied as biocomponent in bioartificial livers: a review.Nibourg GA, Chamuleau RA, van Gulik TM, Hoekstra R
    Expert Opin Biol Ther., Jul 2012
  • Time-Dependent Inhibition and Estimation of CYP3A Clinical Pharmacokinetic Drug-Drug Interactions Using Plated Human Cell Systems.Albaugh DR, Fullenwider CL, Fisher MB, Hutzler JM
    Drug Metab Dispos., Jul 2012
  • Perfusion flow rate substantially contributes to the performance of the HepaRG-AMC-bioartificial liver.Nibourg GA, Boer JD, van der Hoeven TV, Ackermans MT, van Gulik TM,, Chamuleau RA, Hoekstra R
    Biotechnol Bioeng., Jun 2012
  • Liver Progenitor Cell Line HepaRG Differentiated in a Bioartificial Liver Effectively Supplies Liver Support to Rats with Acute Liver Failure.Nibourg GA, Chamuleau RA, van der Hoeven TV, Maas MA, Ruiter AF, Lamers WH, Oude Elferink RP, van Gulik TM, Hoekstra R
    PLoS One, Jun 2012
  • Phosphonium-Containing Diblock Copolymers for Enhanced Colloidal Stability and Efficient Nucleic Acid Delivery.Hemp ST, Smith AE, Bryson JM, Allen MH Jr, Long TE
    Biomacromolecules, Jun 2012
  • Decreased infectivity of nucleoside analogs-resistant hepatitis B virus mutants.Billioud G, Pichoud C, Parent R, Zoulim F
    J Hepatol, Jun 2012
  • Characterization of human cytochrome P450 induction by pesticides.Abass K, Lämsä V, Reponen P, Küblbeck J, Honkakoski P, Mattila S, Pelkonen O, Hakkola J
    Toxicology, May 2012
  • Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: A PXR dependent mechanism.Plée-Gautier E, Antoun J, Goulitquer S, Le Jossic-Corcos C, Simon B, Amet Y, Salaün JP, Corcos L
    Biochem Pharmacol., May 2012
  • Optimization of the HepaRG cell model for drug metabolism and toxicity studies.Anthérieu S
    Toxicology in vitro, May 2012
  • The human hepatocyte cell lines IHH and HepaRG: models to study glucose, lipid and lipoprotein metabolism.Samanez CH
    Arch Physiol Biochem., May 2012
  • An adaptation of the human HepaRG cells to the in vitro micronucleus assay.Jossé R, Rogue A, Lorge E, Guillouzo A
    Mutagenesis, May 2012
  • Co-cultures of enterocytes and hepatocytes for retinoid transport and metabolism.Rossi C
    Toxicol In Vitro, Apr 2012
  • Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins.Gerets HH, Tilmant K, Gerin B, Chanteux H, Depelchin BO, Dhalluin S, Atienzar FA
    Cell Biol Toxicol., Apr 2012
  • Interactions between hepatitis B virus and aflatoxin B(1): effects on p53 induction in HepaRGcells.Lereau M, Gouas D, Villar S, Besaratinia A, Hautefeuille A, Berthillon P, Martel-Planche G, Nogueira da Costa A, Ortiz-Cuaran S, Hantz O, Pfeifer GP, Hainaut P, Chemin I
    J Gen Virol., Mar 2012
  • Hepatocyte polarization is essential for the productive entry of the hepatitis B virus.Schulze A, Mills K, Weiss TS, Urban S
    Hepatology, Feb 2012
  • Antiproliferative and iron chelating efficiency of the new bis-8-hydroxyquinoline benzylamine chelator S1 in hepatocyte cultures.lescoat G, Leonce S, Perré A, Gouffier L, Gaboriau F
    Chem Biol Interact., Jan 2012
  • Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds.Josse R, Dumont J, Fautrel A, Robin MA, Guillouzo A
    Toxicol Appl Pharmacol., Jan 2012
  • The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.Li D, Gaedigk R, Hart SN, Leeder JS, Zhong XB
    Mol Pharmacol., Jan 2012
  • Interindividual variability in gene expression profiles in human hepatocytes and comparison with HepaRG cells.Rogue A, Lambert C, Spire C, Claude N, Guillouzo A
    Drug Metab Dispos, Jan 2012
  • Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs .Zanelli U, Pasquale Caradonna N, Hallifax D, Turlizzi E, Houston JB
    DMD Fast Forward, Jan 2012


  • Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes.Limonciel A, Aschauer L, Wilmes A, Prajczer S, Leonard MO, Pfaller W, Jennings P
    Toxicol In Vitro, Dec 2011
  • Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection.Lucifora J, Arzberger S, Durantel D, Belloni L, Strubin M, Levrero M, Zoulim F, Hantz O
    J Hepatol, Nov 2011
  • CYP4F3B Expression Is Associated with Differentiation of HepaRG Human Hepatocytes and Unaffected by Fatty Acid Overload.Madec S, Cerec V, Plée-Gautier E, Antoun J, Glaise D, Salaun JP, Guguen-Guillouzo C, Corlu A
    Drug Metab Dispos, Oct 2011
  • Predictive Utility of In Vitro Rifampin Induction Data Generated in Fresh and Cryopreserved Human Hepatocytes, Fa2N-4, and HepaRG Cells.Templeton IE, Houston JB, Galetin A
    Drug Metab Dispos, Oct 2011
  • The HepaRG cell line is suitable for bioartificial liver application.Hoekstra R, Nibourg GA, van der Hoeven TV, Ackermans MT, Hakvoort TB, van Gulik TM, Lamers WH
    Int J Biochem Cell Biol, Oct 2011
  • Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters.Picard N, Levoir L, Lamoureux F, Yee SW, Giacomini KM, Marquet P
    Xenobiotica, Sep 2011
  • Automated detection of hepatotoxic compounds in human hepatocytes using HepaRG cells and image-based analysis of mitochondrial dysfunction with JC-1 dye.Pernelle K, Le Guevel R, Glaise D, Stasio CG, Le Charpentier T, Bouaita B, Corlu A, Guguen-Guillouzo C
    Toxicol Appl Pharmacol., Aug 2011
  • Long-term propagation of serum hepatitis C virus (HCV) with production of enveloped HCV particles in human HepaRG hepatocytes.Ndongo-Thiam N, Berthillon P, Errazuriz E, Bordes I, De Sequeira S, Trépo C, Petit MA
    Hepatology, Aug 2011
  • In vitro genotoxicity test approaches with better predictivity: summary of an IWGT workshop.Pfuhler S, Fellows M, van Benthem J, Corvi R, Curren R, Dearfield K, Fowler P, Frötschl R
    Mutat Res., Aug 2011
  • The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation.Sirma H, Kumar M, Meena JK, Witt B, Weise JM, Lechel A, Ande S, Guguen-Guillouzo C
    Gastroenterology, Jul 2011
  • Cytochrome P450-dependent metabolism in HepaRG cells cultured in a dynamic three-dimensional bioreactor.Darnell M, Schreiter T, Zeilinger K, Urbaniak T, Söderdahl T, Rossberg I, Dillnér B, Berg AL
    Drug Metab Dispos, Jul 2011
  • Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitroPawlowska M, Augustin E
    Postepy Hig Med Dosw (Online), Jun 2011
  • Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells.Anthérieu S, Rogue A, Fromenty B, Guillouzo A, Robin MA
    Hepatology, Jun 2011
  • Critical selection of reliable reference genes for gene expression study in the HepaRG cell line.Ceelen L, De Spiegelaere W, David M, De Craene J, Vinken M, Vanhaecke T, Rogiers V
    Biochem Pharmacol., May 2011
  • Comparative gene expression profiles induced by PPARγ and PPARα/γ agonists in human hepatocytes.Rogue A, Lambert C, Jossé R, Antherieu S, Spire C, Claude N, Guillouzo A
    PLoS One, Apr 2011
  • Antiproliferative effect on HepaRG cell cultures of new calix[4]arenes. Part II.Latxague L, Gaboriau F, Chassande O, Leger JM, Pires V, Rouge P, Dassonville-Klimpt A, Fardeau S
    Journal of Enzyme Inhibition, Apr 2011
  • HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity.McGill MR, Yan HM, Ramachandran A, Murray GJ, Rollins DE, Jaeschke H.
    Hepatology, Mar 2011
  • Ethanol Effect on Cell Proliferation in the Human Hepatoma HepaRG Cell Line: Relationship With Iron Metabolism.Tuoi Do TH, Gaboriau F, Ropert M, Moirand R, Cannie I, Brissot P, Loréal O
    Alcohol Clin Exp res., Mar 2011
  • HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro.Lübberstedt M, Müller-Vieira U, Mayer M, Biemel KM, Knöspel F, Knobeloch D, Nüssler AK, Gerlach JC
    J Pharmacol Toxicol Methods, Feb 2011


  • The chinese Herbal Medicine Sophora flavescens Activates Pregnane X Receptor.Wang L, Li F, Lu J, Li G, Zhong XB, Guo G L, Ma X
    Drug Metab Dispos, Dec 2010
  • The use of HepaRG and human hepatocyte data in predicting CYP induction drug-drug interactions via static equation and dynamic mechanistic modelling approaches.Grime K, Ferguson DD, Riley RJ.
    Curr Drug Metab, Dec 2010
  • Prediction of clinical CYP3A4 induction using cryopreserved human hepatocytes.Kaneko A, Kato M, Endo C, Nakano K, Ishigai M, Takeda K
    Xenobiotica, Dec 2010
  • Human hepatoma HepaRG cell line engraftment in severe combined immunodeficient × beige mice using mouse-specific anti-Fas antibody.Jiang L, Li JG, Lan L, Wang YM, Mao Q, You JP
    Transplant Proc, Nov 2010
  • Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines.Dumont J, Jossé R, Lambert C, Anthérieu S, Laurent V, Loyer P, Guillouzo A
    Toxico Appl Pharmacol, Nov 2010
  • Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays.Le Hegarat L, Dumont J, Josse R, Huet S, Lanceleur R, Guguen-Guillouzo C, Guillouzo A
    Mutagenesis, Nov 2010
  • Gene Expression Changes Induced by PPAR Gamma Agonists in Animal and Human Liver.Rogue A, Spire C, Brun M, Claude N, Guillouzo A
    PPAR research, Oct 2010
  • Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression changes.Jennen DG, Gaj S., Giesbertz P.J
    Drug Discovery today, Oct 2010
  • Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.Le Vee M, Jouan E, Fardel O
    Toxicol In Vitro, Sep 2010
  • A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues.Hart SN, Li Y, Nakamoto K, Subileau EA, Steen D, Zhong XB
    Drug Metab Dispos, Jun 2010
  • Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells.Dumont J, Jossé R, Lambert C, Anthérieu S, Le Hegarat L, Aninat C, Robin MA, Guguen-Guillouzo C
    Toxicol Appl Pharmacol., Jun 2010
  • Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification.Jennen DG, Magkoufopoulou C, Ketelslegers HB, van Herwijnen MH, Kleinjans JC, van Delft JH.
    Toxicol Sci., May 2010
  • Entry of hepatitis B virus: mechanism and new therapeutic target.Xie Y, Zhai J, Deng Q, Tiollais P, Wang Y, Zhao M
    Pathol Biol, May 2010
  • General review on in vitro hepatocyte models and their applications.Guguen-Guillouzo C, Guillouzo A
    Methods Mol Biol, May 2010
  • The application of HepRG cells in evaluation of cytochrome P450 induction properties of drug compounds.Andersson TB
    Methods Mol Biol, May 2010
  • The HepaRG cell line: biological properties and relevance as a tool for cell biology, drug metabolism, and virology studies.Marion MJ,, Hantz O, Durantel D
    Methods Mol Biol, May 2010
  • The use of hepatocytes to investigate HDV infection: the HDV/HepaRG model.Sureau C.
    Methods Mol Biol, May 2010
  • Antiproliferative effect on HepaRG cell cultures of new calix[4]arenes.Rouge P, Pires VS, Gaboriau F, Dassonville-Klimpt A, Guillon J, Nascimento SD, Leger JM, Lescoat G
    J Enzyme Inhib Med Chem., Apr 2010
  • Depletion of CoREST does not improve the replication of ICP0 null mutant herpes simplex virus type 1.Everett RD.
    J Virol, Apr 2010
  • Effects of deferasirox and deferiprone on cellular iron load in the human hepatoma cell line HepaRG.Gaboriau F, Leray AM, Ropert M, Gouffier L, Cannie I, Troadec MB, Loréal O, Brissot P
    Biometals, Apr 2010
  • Genotoxicity of a freshwater cyanotoxin, cylindrospermopsin, in two human cell lines: Caco-2 and HepaRG.Bazin E, Mourot A, Humpage AR, Fessard V
    Environ Mol Mutagen, Apr 2010
  • The application of 3D micropatterning of agarose substrate for cell culture and in situ comet assays.Mercey E, Obeïd P, Glaise D, Calvo-Muñoz ML, Guguen-Guillouzo C, Fouqué B
    Biomaterials , Apr 2010
  • The pre-s2 domain of the hepatitis B virus is dispensable for infectivity but serves a spacer function for L-protein-connected virus assembly.Ni Y, Sonnabend J, Seitz S, Urban S
    J Virol, Apr 2010
  • Enrichment of hepatocytes in a HepaRG culture using spatially selective photodynamic treatment.Bednarkiewicz A, Rodrigues RM, Whelan MP
    J Biomed Opt, Mar 2010
  • Highly efficient gene transfer into hepatocyte-like HepaRG cells: new means for drug metabolism and toxicity studies.Laurent V, Fraix A, Montier T, Cammas-Marion S, Ribault C, Benvegnu T, Jaffres PA, Loyer P
    Biotechnol J., Mar 2010
  • Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells.Anthérieu S, Chesné C, Li R, Camus S, Lahoz A, Picazo L, Turpeinen M, Tolonen A
    Drug Metab Dispos, Mar 2010
  • Stem cell-derived hepatocytes and their use in toxicology.Guguen-Guillouzo C, Guillouzo A, Corlu A
    Toxicology, Mar 2010
  • Fine mapping of pre-S sequence requirements for hepatitis B virus large envelope protein-mediated receptor interaction.Schulze A, Schieck A, Ni Y, Mier W, Urban S
    J Virol, Feb 2010
  • Control of hepatitis B virus replication by innate response of HepaRG cells.Lucifora J, Durantel D, Testoni B, Hantz O, Levrero M, Zoulim F
    Hepatology, Jan 2010
  • Hepatitis B virus requires intact caveolin-1 function for productive infection in HepaRG cells.Macovei A, Radulescu C, Lazar C, Petrescu S, Durantel D, Dwek RA, Zitzmann N, Nichita NB.
    J Virol , Jan 2010
  • Synthesis and biological properties of iron chelators based on a bis-2-(2-hydroxy-phenyl)-thiazole-4-carboxamide or -thiocarboxamide (BHPTC) scaffold.Rodriguez-Lucena D, Gaboriau F, Rivault F, Schalk IJ, Lescoat G, Mislin GL
    Bioorg Med chem, Jan 2010


  • Effects of deferasirox and deferiprone on cellular iron load in the human hepatoma cell line HepaRG.Gaboriau F, Leray AM, Ropert M, Gouffier L, Cannie I, Troadec MB, Loréal O, Brissot P, Lescoat G
    Biometals, Dec 2009
  • The pre-S1 and antigenic loop infectivity determinants of the hepatitis B virus envelope proteins are functionally independent.Le Duff Y, Blanchet M, Sureau C
    J Virol, Dec 2009
  • HepaRG cells engraftment treats acute liver failure in severe combined immunodeficient mice after mouse-specific anti-Fas antibody inducement.Jiang L, Lan L, Li J, Wang Y, Liu G
    J Third Mil Med Univ, Nov 2009
  • Repopulation of bcl 2 gene transfection on HepaRG cells in an animal model of severe combined immunodeficient mice with chimeric human liver using mouse specific anti fas antibody.Jiang L, Lan L, Li J
    China Academic journ, Nov 2009
  • Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression.Legendre C, Hori T, Loyer P, Aninat C, Ishida S, Glaise D, Lucas Clerc C, Boudjema K
    Eur J Cancer , Nov 2009
  • In vitro model for the prediction of clinical CYP3A4 induction using HepaRG cells.Kaneko A, Kato M, Sekiguxhi N, Mitsui T, Takeda K, Aso Y
    Xenobiotica, Nov 2009
  • The first transmembrane domain of the hepatitis B virus large envelope protein is crucial for infectivity.Lepère Douard C, Trotard M, Le Seyec J, Gripon P
    J Virol, Nov 2009
  • Inhibition of the binding of HCV serum particles to human hepatocytes by E1E2-specific D32.10 monoclonal antibody.Ndongo N, Rechoum Y, De Sequeira S, Zoulim F, Trépo C, Douet E, Petit MA
    J Med Virol, Oct 2009
  • Inhibitory effect of the combination of CpG-induced cytokines with lamivudine against hepatitis B virus replication in vitro.Vincent IE, Lucifora J, Durantel D, Hantz O, Chemin I, Zoulim F, Trepo C
    Antivir Ther., Jul 2009
  • Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells.McGinnity DF, Zhang G, Kenny JR, Hamilton GA, Otmani S, Stams KR, Haney S, Brassil P
    Drug Metab Dispos, Jun 2009
  • Functional expression, inhibition and induction of CYP enzymes in HepaRG cells.Turpeinen M, Tolonen A, Chesne C, Guillouzo A, Uusitalo J, Pelkonen O
    Toxicol. In Vitro, Jun 2009
  • Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions.Lambert CB, Spire C, Renaud MP, Claude N, Guillouzo A
    Toxicol In Vitro, Apr 2009
  • Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells.Lambert CB, Spire C, Claude N, Guillouzo A
    Toxicol Appl Pharmacol., Feb 2009
  • In vitro characterization of viral fitness of therapy-resistant hepatitis B variants.Villet S, Billioud G, Pichoud C, Lucifora J, Hantz O, Sureau C, Dény P, Zoulim F
    Gastroenterology, Jan 2009
  • La place des méthodes in silico, in vitro, in omic dans l'évaluation de la sécurité des médicaments.Claude n, Goldfain-Blanc F, Guillouzo A
    Med Sci, Jan 2009
  • Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocyte-like cells.Hantz O, Parent R, Durantel D, Gripon P, Guguen Guillouzo C, Zoulim F
    J Gen Virol, Jan 2009
  • Proteomic analysis of HepaRG cells: a novel cell line that supports hepatitis B virus infection.Narayan R, Gangadharan B, Hantz O, Antrobus R, Garcia A, Dwek RA, Zitzmann N
    J Proteome Res., Jan 2009


  • New perspectives in the use of human hepatocytes in the preclinical drug development processGuillouzo A
    Ann Pharm Fr, Nov 2008
  • CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis.Antoun J, Goulitquer S, Amet Y, Dreano Y, Salaun JP, Corcos L, Plée-Gautier E
    J Lipid Res, Oct 2008
  • Evolving concepts in liver tissue modeling and implications for in vitro toxicology.Guillouzo A, Guguen-Guillouzo C
    Expert Opin Drug Metab Toxicol, Oct 2008
  • Initiation of hepatitis B virus genome replication and production of infectious virus following delivery in HepG2 cells by novel recombinant baculovirus vector.Lucifora J, Durantel D, Belloni L, Barraud L, Villet S, Vincent IE, Margeridon-Thermet S, Hantz O
    J Gen Virol, Aug 2008
  • Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies.Kanebratt KP, Andersson TB
    Drug Metab Dispos, Jul 2008
  • Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies.Jossé R, Aninat C, Glaise D, Dumont J, Fessard V, Morel F, Poul JM, Guguen-Guillouzo C
    Drug Metab Dispos, Jun 2008
  • Amiodarone-Induced Phospholipidosis And Steatosis In Human Hepatoma HepaRG Cells.Aninat C, Piton A, Glaise D, Le Charpentier T, Langouët S, Morel F, Guguen-Guillouzo C, Guillouzo A, Jossé R, Fessard V, Poul JM
    Univ Rennes 1, May 2008
  • Characterization of the double-stranded RNA responses in human liver progenitor cells.Maire M, Parent R, Morand AL, Alotte C, Trépo C, Durantel D, Petit MA
    Biochem Biophys Res Commun, Apr 2008
  • Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes.Petit E, Langouet S, Akhdar H, Nicolas-Nicolaz C, Guillouzo A, Morel F
    Toxicol In vitro, Apr 2008
  • Catecholamines induce an inflammatory response in human hepatocytes.Aninat C, Seguin P, Descheemaeker PN, Morel F, Malledant Y, Guillouzo A
    Crit Care Med, Mar 2008
  • Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta.Le Vee M, Gripon P, Stieger B, Fardel O
    Drug Metab Dispos, Feb 2008
  • HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans.Kanebratt KP, Andersson TB
    Drug Metab Dispos, Jan 2008
  • Translational control plays a prominent role in the hepatocytic differentiation of HepaRG liver progenitor cells.Parent R, Beretta L
    Genome Biol., Jan 2008


  • Entry of hepatitis delta virus requires the conserved cysteine residues of the hepatitis B virus envelope protein antigenic loop and is blocked by inhibitors of thiol-disulfide exchange.Abou Jaoudé G, Sureau C
    J Virol, Dec 2007
  • Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans.Schulze A, Gripon P, Urban S
    Hepatology, Dec 2007
  • Highly sensitive upregulation of apolipoprotein A-IV by peroxisome proliferator-activated receptor alpha (PPARalpha) agonist in human hepatoma cells.Nagasawa M, Akasaka Y, Ide T, Hara T, Kobayashi N, Utsumi M, Murakami K
    biochem pharmacol., Dec 2007
  • Infectivity Determinants of the Hepatitis B Virus Pre-S Domain Are Confined to the N-Terminal 75 Amino Acid Residues.Blanchet M, Sureau C
    J Virol, Jun 2007
  • Mammalian target of rapamycin activation impairs hepatocytic differentiation and targets genes moderating lipid homeostasis and hepatocellular growth.Parent R, Kolippakkam D, Booth G, Beretta L
    Cancer Res, May 2007
  • The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics.Guillouzo A, Corlu A, Aninat C, Glaise D, Morel F, Guguen-Guillouzo C
    Chem Biol Interact., May 2007
  • Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor.Cerec V, Glaise D, Garnier D, Morosan S, Turlin B, Drenou B, Gripon P, Kremsdorf D
    Hepatology , Apr 2007
  • How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.Kirkland D, Pfuhler S, Tweats D, Aardema M, Corvi R, Darroudi F, Elhajouji A, Glatt H
    Mutat Res., Mar 2007
  • Determination of genetic toxicity and potential carcinogenicity in vitro--challenges post the Seventh Amendment to the European Cosmetics Directive.Tweats DJ, Scott AD, Westmoreland C, Carmichael PL
    Mutagenesis, Jan 2007
  • Viral and cellular determinants involved in hepadnaviral entry.Glebe D, Urban S
    World J Gastroenterol., Jan 2007


  • Analysis of the cytosolic domains of the hepatitis B virus envelope proteins for their function in viral particle assembly and infectivity.Blanchet M, sureau C
    J Virol, Dec 2006
  • CYP4A11 is repressed by retinoic acid in human liver cells.Antoun J, Amet Y, Simon B, Dréano Y, corlu A, Corcos L, Salaun JP, Plée Gautier E
    FEBS Lett, Jun 2006
  • Lipid-mediated introduction of hepatitis B virus capsids into nonsusceptible cells allows highly efficient replication and facilitates the study of early infection events.Rabe B, Glebe D, Kann M
    J Virol, Jun 2006
  • Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line.Le Vee M, Jigorel E, Glaise D, Gripon P, Guguen-Guillouzo C, Fardel O
    Eur J Pharm, May 2006
  • Characterization of a hepatitis B and hepatitis delta virus receptor binding site.Engelke M, Mills K, Seitz S, Simon P, Gripon P, Schnölzer M, Urban S
    Hepatology, Apr 2006
  • Metabolism: a bottleneck in in vitro toxicological test development.Coecke S, Ahr H, Blaauboer B, , Bremer S, Casati S, Castell J, Combes R, Corvi R, Crespi CL, Cunningham ML, , Elaut G, Eletti B, Freidig A, Gennari A, Ghersi-Egea JF, Guillouzo A, Hartung T, Hoet P, Ingelman-Sundberg M, Munn S, Janssens W, Ladstetter B
    ATLA, Feb 2006
  • Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells.Aninat C, Piton A, Glaise D, Le Charpentier T, Langouët S, Morel F, Guguen-Guillouzo C, Guillouzo A
    Drug Metab Dispos, Jan 2006
  • Hepatocyte iron loading capacity is associated with differentiation and repression of motility in the HepaRG cell line.Troadec MB, Glaise D, Lamirault G, Le Cunff M, Guérin E, Le Meur N, Détivaud L, Zindy P
    Genomics, Jan 2006


  • Role of the antigenic loop of the hepatitis B virus envelope proteins in infectivity of hepatitis delta virus.Jaoudé GA, Sureau C
    J Virol, Aug 2005
  • Increase of doxorubicin sensitivity by doxorubicin-loading into nanoparticles for hepatocellular carcinoma cells in vitro and in vivo.Barraud L, Merle P, Soma E, Lefrançois La, Guerret S, Chevallier M, Dubernet C, Couvreur P
    J Hepatol, May 2005
  • Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein.Gripon P, Cannie I, Urban S
    J Virol, Feb 2005


  • HepaRG: a novel human differentiated hepatoma cell line exhibiting high levels of inducible CYP450s and GSTs enzymes useful for pharmacological and toxicological applications.Cerec V, Corlu A, Glaise D, Guguen-Guillouzou C, Gripon P
    Poster Hug meeting, Nov 2004
  • Origin and characterization of a human bipotent liver progenitor cell line.Parent R, Marion MJ, Furio L, Trépo C, Petit MA
    Gastroenterology, Apr 2004


  • Hypothermic Storage and Cryopreservation of Hepatocytes: The Protective Effect of Alginate Gel Against Cell DamagesMahler S, Desille M, Frémond B, Chesné C, Guillouzo A, Campion JP, Clément B, , , , , ,
    Cell Transplant., Dec 2003
  • Role of N glycosylation of hepatitis B virus envelope proteins in morphogenesis and infectivity of hepatitis delta virus.Sureau C., Fournier-Wirth C, Maurel P
    J Virol, May 2003


  • Infection of a human hepatoma cell line by hepatitis B virus.Gripon P, Rumin S, Urban S, Le Seyec J, Glaise D, Cannie I, Guyomard C, Lucas J
    Poc Natl Acad Sci, Nov 2002

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