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Poster HepaRG

 




ADME

FARNESOL SUPPRESSES LIPID ACCUMULATION IN HepaRG CELL BASED MODEL OF HEPATIC STEATOSIS.
Asmita Pant1, and Thomas A. Kocarek1
Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48201

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Evaluation of a single-well cytochrome CYP3A4/5, 1A2 and 2B6 induction assy using hepatocytes dervied from HepaRG™ cell line. - ISSX 2014
Rachel Mandell Basile1, Gary Park1, David Sweeny1, Maurice Standlee1, Susan Grepper2, David Lau1
Department of Drug Metabolism and Pharmacokinetics, Rigel Pharmaceuticals, South San Francisco, CA
CellzDirect/Life Technologies, Durham, NC 

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Evaluation of differentiated cryopreserved HepaRG cells as a model for hepatic clearance and UGT activity. - Rennes Workshop 2011
Malin Darnell1,2 and Tommy B Andersson1,2
AstraZeneca R&D, Sweden
Karolinska Institute, Stockholm, Sweden

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Measuring CYP3A induction in combination with cell viability in multiplex cell-based assays formats- ISSX 2010
James J. Cali1, Marie Sobol1, James Unch1, Thimothy Moeller2, Brad Larson3 and David Steen4
1 Promega Corp
2 Celsis/IVT inc
3 Biotek Instruments
4 Biopredic International

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Prediction of clearance from the HepaRG cell system: comparison with human hepatocytes for a range of substrates. - ISSX 2010
Ugo Zanelli1, Nicola Pasquale Caradonna1, David Hallifax2 and James Brian Houston2
1 Met profiling unit, Screening & Technology department, Siena Biotech, Strada del Petriccio e Belriguardo, 35, 53100 Siena, Italy
2 School of Pharmacy and Pharmaceuticals Sciences, The university of Manchester, Manchester, UK


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Nuclear Receptor Signaling in HepaRG Cells. - ISSX 2009
Dan Brobst1 and Jeff L. Staudinger1
1 Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045 

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TOXICOLOGY

 

 

Human HepaRG™ cells, a useful in vitro model for cell-based cholestasis assays - ISSX Orlando 2015
F.Brée1, S.camus3, D.Steen13, C.Guguen-Guillouzo2-3
Eurosafe, Parc d’affaires de la Breteche, Bat B1, F-35760- Saint Grégoire – francoise.bree@eurosafe.fr
Inserm UMT991, F-35000-Rennes
Biopredic International, Parc d’affaires de la Breteche, Bat A4, F-35760- Saint Grégoire

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A High-Content Analysis Assay to Predict Human Hepatotoxicity in HepaRG and HepG2 cells - SOT 2015
Junichiro Saito1, Ai Okamura1, Kenichiro Takeuchi1, Kenichi Hanioka1, Akinobu Okada1, and Takeji Ohata2
Drug Safety Research Labs. Astellas Pharma Inc, Osaka, Japan.
Research Program Management Office, Astellas Pharma Inc, Miyukigaoka, Japan.

 

Identification of drug-induced mitochondrial alterations using the HepaRG™ cell line. - ISSX 2014
Nelly Buron1, Matthieu Porceddu1, Claire Pertuiset1, David Steen2, Sandrine Camus2, Christophe Chesné2 and Anne Borgne-Sanchez1
1 Mitologics S.AS, Paris, France
2 Biopredic International, Saint Grégoire, France 

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Analysis of Four Hepatotoxicants Using the xCELLigence Analytical System and HepaRG Cells- SOT 2014
Can Jin1, David Steen2, Valery Schevchenko2, Christophe Chesne and Yama Abassi1
1 ACEA Biosciences, San Diego, CA

2 Biopredic International, Saint-Grégoire France 


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New insights in dose-dependent mechanisms involved in cyclosporine A-induced cholestasis in HepaRG cells. Comparison with tacrolimus- SOT 2014
Ahmad Sharanek 1,2, Pamela Bachour-El Azzi 1,2, Houssein Al-Attrache 1,2, Camille C. Savary1,2, Christiane Guguen-Guillouzo1,2,3 and André Guillouzo 1,2
1 Inserm UMR991, Liver and Metabolisms Cancer, Rennes, France

2 University of Rennes 1, Rennes, France
3 Biopredic International, St Grégoire, France 
 View the related publication


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Characterization of Cryopreserved HepaRG Cells for Multiparameter High Content Analysis. - SOT 2012
Aarati Ranade1, Simone Graeber1, Philip Hewitt1, Stefan O. Mueller1, Jeff Till1, Andrew J. Ball1
Merck Millipore

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Acetaminophen-induced injury in HepaRG cells: a novel human cell line for studies of drug hepatotoxicity. - SOT 2010
Mitchell R. McGill1, Huimin Yan1, Anup Ramachandran1 and Hartmut Jaeschke1
1 
Department of Pharmacology, Toxicology, & Therapeutics, University of Kansas Medical Center, Kansas City, KS

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In vitro models for the assessment of drug-induced mitochondrial dysfunction. - Elrig 2013
Conn Carey1, Ian Hayes1 and James Hynes1
1 
Luxcel Biosciences, BioInnovation Centre, UCC, Cork, Ireland.

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Gene expression profiles in HepaRG cells to discriminate genotoxic from non genotoxic compounds. EEMS 2012
D. Giret1, A. Huguet1, S.Camus2, N. Rougier2, C.Chesné2, V. Fessard1 and L. Le Hegarat1

1 
French Agency for Food, Environmental and Occupational Health & Safety, Toxicology of contaminants Unit, Fougères, France
2 Biopredic International, Saint-Grégoire, France

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Comparison of Different Cell Models in High Content Screening to Investigate Metabolism-Mediated Hepatotoxicity 2011
Walker, Paul1; Fox, Katie1; Butler, Phil1; Annand, Robert1,3; Mouchet, Nicolas2; Camus, Sandrine2; Dilworth, Clive1; Chesne, Christophe2; Gill, Helen1; Tsaioun, Katya1,3
1 Cyprotex, Macclesfield, United Kingdom

2 Biopredic, Rennes, France
3 Apredica, Watertown, MA, United States 
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Amiodarone-Induced Phospholipidosis And Steatosis In Human Hepatoma HepaRG Cells. - Liintop Project 2009
Sébastien Anthérieu1, Christophe Chesné2, André Guillouzo1
INSERM U620-MDC, Université de Rennes1, Rennes, France
Biopredic International, Rennes, France
View the related publication

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INNOVATIVE MODES OF CULTURE

Evaluation of the impact of matrix stiffness on encapsulated HepaRG spheroids. - ESACT 2013
Sofia P Rebelo1,2, Marta Estrada1,2, Rita Costa1,2, Christophe Chesné3, Catarina Brito1,2 and Paula M Alves1,2
1 iBET, Instituto de Biologia Experimental e Tecnológica, 2780-901 Oeiras, Portugal.
2 Instituto de tecnologia Quimica e Biologica, Universida de Nova de Lisboa, 2780-157 Oeiras, Portugal

3 Biopredic International, Saint-Grégoire, France

 
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The human hepatic cell line HepaRG as a possible cell source for the steady generation of humanized liver TK-NOG mice. - CIEA 2013
Hiroshi Suemizu1,Yuichiro Yiguchi1, Kenji Kawai1, Hiroshi Yamazaki2, Françoise Bree3, Christiane Guguen-Guillouzo4 and Masato Nakamura5
1 Central Institute of experimental animals.
2 Showa Pharmaceutical University

3 Xenoblis
4 Biopredic International
5 Tokai university school of medicine 

 
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Alterations of the Bile Acid transport system by Cyclosporine A in HepaRG cells. - EUSAAT 2013
Ahmad Sharanek1,2, Pamela Bachour-El Azzi1,2,3, Christiane Guguen-Guillouzo1,2,4, and Andre Guillouzo1,2
1
Inserm UMR991, Liver Metabolisms and Cancer, Rennes, France
2 University of Rennes 1, Rennes, France
3 Lebanese university, Lebanon
4 Biopredic International, St Grégoire, France. 
View publications 

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INFECTIOUS DISEASES

Human HepaRG cells Support L ongTerm Propaga-tion of Hepatitis C Virus (HCV) : Candidate Infection System for Screening Entry Inhibitors. - EASL 2012
Marie-Anne Petit1,2, N diém-é Ndongo1,2, Pascale Berthillon1,2, and Christian Trépo1,2,3
1 Centre de Recherche en C ancérologie de Lyon (CRCL), INSERM U1052/CNRS UMR5286
2 151 Cours Albert Thomas, 69424 Lyon Cedex 03, France; Université Claude Bernard Lyon 1, 69008 Lyon, France

3 Hospices Civils de Lyon, Hôpital de la Croix Rousse, Service d’Hépatologie et de Gastroentérologie, 69004 Lyon, France
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