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The most innovative and useful hepatic cell line

HeparRG™ is an unique and well established hepatic cell system able to produce early hepatic progenitor cells as well as completely mature human hepatocytes.

The one-stop hepatic in-vitro model for:

  • In-vitro ADME applications: Inhibition assays, Drug metabolism and clearance, Metabolite ID...
  • In-vitro toxicity testing applications: Hepatotoxicity (reactive metabolites, lipidosis, choleastasis etc), Virology (HBV, HCV…), Infection with hepatitis and other viruses for replication, ...
  • Liver assist devices/ BioArtificial Livers 
  • Transgenic liver humanized animals with HepaRG™ cells
  • …. an ever-expanding range of applications!

HeparRG™ cells are more economical, convenient, and predictable than fresh or cryopreserved primary human hepatocytes. It's available in proliferative state to be expanded and differentiated in-house, or as cryopreserved, fully differentiated and ready-to-use hepatic cells.





Features of the HepaRG™ cells

HeparRG™ is an immortalised cell line with 4 main features:

  • Full array of functions, responses, and regulatory pathways of primary human hepatocytes including:Phase I and II, and transporter activities consistent with those found within a population of primary human hepatocytes + Intact response elements, PXR, CAR and PPARa
  • Form bile canaculi
  • Has the potential to express major properties of stem cells
  • High plasticity & complete transdifferentiation capacity

heparg publications

Latest publications

  • Metabolomics profiling of steatosis progression in HepaRG® cells using sodium valproate.Cuykx M,  Claes L,  Rodrigues RM,  Vanhaecke T,  Covaci A
    Toxicol Lett, Jan 2018
  • Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells.Ogasawara A,  Kato N,  Torimoto N,  Aohara F,  Ohashi R,  Yamada Y,  Taniguchi H, , , , , ,
    Drug Metab Lett., Jan 2018
All publications on HepaRG

Upcoming HepaRG training sessions

Do you want to know more about the using of our HepaRG™ products? Register to our next HepaRG training sessions!
  • 25th and 26th of January 2018

register training session

What's new ?

Heparg on a CAAT ACADEMY Workshop on November 2017

HepaRG in a workshop in Turkey Read more

HepaRG presentation by Stephen Ferguson - October 2017

HepaRG under the spotlight in a Stephen Ferguson presentation. in October 2017  Read more
See all the news  

HepaRG™ model system for cholestasis prediction

Time lapse (Total recording time: 2 hours).
Chlormoprazine superior to 40µM constricts the bile lumen and provokes cholestasis.
Constriction of canaliculus lumen has been observed in presence of CPZ after 2 hours.

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